Anne A Knowlton

Internal Medicine, Cardiovascular Medicine

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Anne A Knowlton

• Departments
  Internal Medicine
  
  Cardiovascular Medicine
  
  

  Current Appointments:

  Prof

  
  
  
Current Appointments:
Prof

H-Index:30

This is a list of publications by this researcher, listed chronologically starting with the most recent first. New publications appear in this list weekly. The source of publications and 'cited by' data for this application is Scopus.

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• 1.

  2012

  Somak Das; Subhendu Mukherjee; Istvan Lekli; Narasimman Gurusamy; Jayeeta Bardhan; Utpal Raychoudhury; Runu Chakravarty; Sandip Banerji; Anne A. Knowlton; Dipak K. Das

  Tocotrienols confer resistance to ischemia in hypercholesterolemic hearts: Insight with genomics

  Molecular and Cellular Biochemistry. 2012;360(1-2):35-45.
  1

• 2.

  2012

  Anne A Knowlton

  Estrogen and cardiovascular disease: Aging and estrogen loss at the heart of the matter?

  Future Cardiology. 2012;8(1):9-12.
  0

• 3.

  2012

  Angela S. Pechenino; Alison R. Lee; Li Lin; Fiona N. Mbai; John N. Stallone; A.A. Knowlton

  Reply to "Letter to the Editor: 'Understanding the WHI gap'"

  Physiological Genomics. 2012;44(5):330.
  0

• 4.

  2012

  Anne A. Knowlton; Le Chen

  Regulating a uniter: Control of mitofusin 2 expression

  Cardiovascular Research. 2012;94(1):6-7.
  0

• 5.

  2012

  Anne A. Knowlton

  The aging heart and estrogen

  Aging Health. 2012;8(2):163-166.
  0

• 6.

  2012

  A.A. Knowlton; A.R. Lee

  Estrogen and the cardiovascular system

  Pharmacology and Therapeutics. 2012;135(1):54-70.
  3

• 7.

  2012

  Sanda Despa; Kenneth B. Margulies; Le Chen; Anne A. Knowlton; Peter J. Havel; Heinrich Taegtmeyer; Donald M. Bers; Florin Despa

  Hyperamylinemia contributes to cardiac dysfunction in obesity and diabetes: A study in humans and rats

  Circulation Research. 2012;110(4):598-608.
  1

• 8.

  2012

  James P. Stice; Fiona N. Mbai; Le Chen; Anne A. Knowlton

  Rapid activation of nuclear factor κb by 17β-estradiol and selective estrogen receptor modulators: Pathways mediating cellular protection

  Shock. 2012;38(2):128-136.
  0

• 9.

  2012

  Chongxiu Sun; Kenan Alkhoury; Ying I. Wang; Greg A. Foster; Christopher E. Radecke; Kayan Tam; Christina M. Edwards; Marc T. Facciotti; Ehrin J. Armstrong; Anne A. Knowlton; et al.

  IRF-1 and miRNA126 modulate VCAM-1 expression in response to a high-fat meal

  Circulation Research. 2012;111(8):1054-1064.
  0

• 10.

  2012

  Claudio Blasi; Eunjung Kim; Anne A. Knowlton

  Improved metabolic control in diabetes, HSP60, and proinflammatory mediators

  Autoimmune Diseases. 2012;1(1).
  0

• 11.

  2011

  R. Michael Gower; Huaizhu Wu; Greg A. Foster; Sridevi Devaraj; Ishwarlal Jialal; Christie M. Ballantyne; Anne A. Knowlton; Scott I. Simon

  CD11c/CD18 Expression is upregulated on blood monocytes during hypertriglyceridemia and enhances adhesion to vascular cell adhesion molecule-1

  Arteriosclerosis, Thrombosis, and Vascular Biology. 2011;31(1):160-166.
  16

• 12.

  2011

  James P. Stice; Le Chen; Se-Chan Kim; J.S. Jung; A.L. Tran; T.T. Liu; Anne A. Knowlton

  17β-estradiol, aging, inflammation, and the stress response in the female heart

  Endocrinology. 2011;152(4):1589-1598.
  8

• 13.

  2011

  Samuel Kobba; Se-Chan Kim; Le Chen; Eunjung Kim; Alice L. Tran; Pascal Knuefermann; Anne A. Knowlton

  The heat shock paradox and cardiac myocytes: Role of heat shock factor

  Shock. 2011;35(5):478-484.
  6

• 14.

  2011

  Angela S. Pechenino; Li Lin; Fiona N. Mbai; Alison R. Lee; Xian-Min He; John N. Stallone; A.A. Knowlton

  Impact of aging vs. estrogen loss on cardiac gene expression: Estrogen replacement and inflammation

  Physiological Genomics. 2011;43(18):1065-1073.
  10

• 15.

  2011

  Le Chen; A.A. Knowlton

  Mitochondrial dynamics in heart failure

  Congestive Heart Failure. 2011;17(6):257-261.
  1

• 16.

  2010

  Y. Wang; L. Chen; N. Hagiwara; A.A. Knowlton

  Regulation of heat shock protein 60 and 72 expression in the failing heart

  Journal of Molecular and Cellular Cardiology. 2010;48(2):360-366.
  12

• 17.

  2010

  Simone Filosto; William Fry; Anne A. Knowlton; Tzipora Goldkorn

  Neutral sphingomyelinase 2 (nSMase2) is a phosphoprotein regulated by calcineurin (PP2B)

  Journal of Biological Chemistry. 2010;285(14):10213-10222.
  15

• 18.

  2010

  L. Chen; A.A. Knowlton

  Mitochondria and heart failure: New insights into an energetic problem

  Minerva Cardioangiologica. 2010;58(2):213-229.
  9

• 19.

  2010

  Dipika Tuteja; Sassan Rafizadeh; Valeriy Timofeyev; Shuyun Wang; Zheng Zhang; Ning Li; Robertino K. Mateo; Anil Singapuri; J. Nilas Young; Anne A. Knowlton; et al.

  Cardiac small conductance Ca²⁺-activated K⁺ channel subunits form heteromultimers via the coiled-coil domains in the C termini of the channels

  Circulation Research. 2010;107(7):851-859.
  19

• 20.

  2009

  James P. Stice; Jason P. Eiserich; A.A. Knowlton

  Role of aging versus the loss of estrogens in the reduction in vascular function in female rats

  Endocrinology. 2009;150(1):212-219.
  16

• 21.

  2009

  James P. Stice; Jennifer S. Lee; Angela S. Pechenino; Anne A. Knowlton

  Estrogen, aging and the cardiovascular system

  Future Cardiology. 2009;5(1):93-103.
  17

• 22.

  2009

  Le Chen; Qizhi Gong; James P. Stice; Anne A. Knowlton

  Mitochondrial OPA1, apoptosis, and heart failure

  Cardiovascular Research. 2009;84(1):91-99.
  54

• 23.

  2009

  Se-Chan Kim; James P. Stice; Le Chen; James S. Jung; Sanjiv Gupta; Yin Wang; Georg Baumgarten; Joann Trial; Anne A. Knowlton

  Extracellular heat shock protein 60, cardiac myocytes, and apoptosis

  Circulation Research. 2009;105(12):1186-1195.
  32

• 24.

  2008

  Karyn L. Hamilton; Li Lin; Yin Wang; Anne A. Knowlton

  Effect of ovariectomy on cardiac gene expression: Inflammation and changes in SOCS gene expression

  Physiological Genomics. 2008;32(2):254-263.
  16

• 25.

  2008

  Anne A. Knowlton; Uma Srivatsa

  Heat-shock protein 60 and cardiovascular disease: A paradoxical role

  Future Cardiology. 2008;4(2):151-161.
  3

• 26.

  2008

  James P. Stice; Anne A. Knowlton

  Estrogen, NFκB, and the heat shock response

  Molecular Medicine. 2008;14(7-8):517-527.
  33

• 27.

  2008

  Charles L. Stebbins; James P. Stice; C. Michael Hart; Fiona N. Mbai; Anne A. Knowlton

  Effects of dietary decosahexaenoic acid (DHA) on eNOS in human coronary artery endothelial cells

  Journal of Cardiovascular Pharmacology and Therapeutics. 2008;13(4):261-268.
  11

• 28.

  2007

  Anne A. Knowlton

  Life, death, the unfolded protein response and apoptosis

  Cardiovascular Research. 2007;73(1):1-2.
  3

• 29.

  2007

  Ling Lu; Qian Zhang; Valeriy Timofeyev; Zhao Zhang; J Nilas Young; Hee-Sup Shin; Anne A. Knowlton; Nipavan Chiamvimonvat

  Molecular coupling of a Ca2+-activated K+ channel to L-type Ca2+ channels via α-actinin2

  Circulation Research. 2007;100(1):112-120.
  40

• 30.

  2007

  Harold J. Ting; James P. Stice; Ulrich Y. Schaff; David Y. Hui; John C. Rutledge; Anne A. Knowlton; Anthony G. Passerini; Scott I. Simon

  Triglyceride-rich lipoproteins prime aortic endothelium for an enhanced inflammatory response to tumor necrosis factor-α

  Circulation Research. 2007;100(3):381-390.
  50

• 31.

  2007

  Se-Chan Kim; Bum-Soo Kim; Li Lin; Anne A. Knowlton

  Heat shock proteins - Two sides of a coin

  Current Cardiology Reviews. 2007;3(2):143-148.
  1

• 32.

  2007

  Sanjiv Gupta; A.A. Knowlton

  HSP60 trafficking in adult cardiac myocytes: Role of the exosomal pathway

  American Journal of Physiology - Heart and Circulatory Physiology. 2007;292(6):H3052-H3056.
  47

• 33.

  2007

  Se-Chan Kim; Alexander Ghanem; Heidi Stapel; Klaus Tiemann; Pascal Knuefermann; Andreas Hoeft; Rainer Meyer; Christian Grohé; Anne A. Knowlton; et al.

  Toll-like receptor 4 deficiency: Smaller infarcts, but nogain in function

  BMC Physiology. 2007;7.
  37

• 34.

  2007

  Li Lin; S.C. Kim; Yin Wang; S. Gupta; B. Davis; S.I. Simon; G. Torre-Amione; A.A. Knowlton

  HSP60 in heart failure: Abnormal distribution and role in cardiac myocyte apoptosis

  American Journal of Physiology - Heart and Circulatory Physiology. 2007;293(4):H2238-H2247.
  49

• 35.

  2006

  A.A. Knowlton

  NFκB, heat shock proteins, HSF-1, and inflammation

  Cardiovascular Research. 2006;69(1):7-8.
  19

• 36.

  2006

  Georg Baumgarten; Pascal Knuefermann; Gerrit Schuhmacher; Volker Vervölgyi; Joscha Von Rappard; Ulrike Dreiner; Klaus Fink; Chryso Djoufack; Andreas Hoeft; et al.

  Toll-like receptor 4, nitric oxide, and myocardial depression in endotoxemia

  Shock. 2006;25(1):43-49.
  57

• 37.

  2005

  Fiona N. Mbai; Karyn L. Hamilton; Anne A. Knowlton

  Gender differences in cardiovascular disease: The effects of estrogen

  Drug Discovery Today: Disease Mechanisms. 2005;2(1):65-70.
  0

• 38.

  2005

  F.N. Mbai; A.A. Knowlton

  Aging, ischemia and the heart

  Journal of Molecular and Cellular Cardiology. 2005;38(2):241-244.
  1

• 39.

  2005

  S. Gupta; A.A. Knowlton

  HSP60, Bax, apoptosis and the heart

  Journal of Cellular and Molecular Medicine. 2005;9(1):51-58.
  78

• 40.

  2005

  M.R. Voss; S. Gupta; J.P. Stice; G. Baumgarten; L. Lu; J.M. Tristan; A.A. Knowlton

  Effect of mutation of amino acids 246-251 (KRKHKK) in HSP72 on protein synthesis and recovery from hypoxic injury

  American Journal of Physiology - Heart and Circulatory Physiology. 2005;289(6 58-6):H2519-H2525.
  10

• 41.

  2004

  Karyn L. Hamilton; S. Gupta; A.A. Knowlton

  Estrogen and regulation of heat shock protein expression in female cardiomyocytes: Cross-talk with NFκB signaling

  Journal of Molecular and Cellular Cardiology. 2004;36(4):577-584.
  40

• 42.

  2004

  JoAnn Trial; Roger D. Rossen; Jose Rubio; Anne A. Knowlton

  Inflammation and ischemia: Macrophages activated by fibronectin fragments enhance the survival of injured cardiac myocytes

  Experimental Biology and Medicine. 2004;229(6):538-545.
  24

• 43.

  2004

  Karyn L. Hamilton; F.N. Mbai; S. Gupta; A.A. Knowlton

  Estrogen, heat shock proteins, and NFκB in human vascular endothelium

  Arteriosclerosis, Thrombosis, and Vascular Biology. 2004;24(9):1628-1633.
  23

• 44.

  2003

  Biykem Bozkurt; Ildiko Agoston; A.A. Knowlton

  Complications of inappropriate use of spironolactone in heart failure: When an old medicine spirals out of new guidelines

  Journal of the American College of Cardiology. 2003;41(2):211-214.
  138

• 45.

  2003

  M.R. Voss; J.N. Stallone; Min Li; R.N.M. Cornelussen; P. Knuefermann; A.A. Knowlton

  Gender differences in the expression of heat shock proteins: The effect of estrogen

  American Journal of Physiology - Heart and Circulatory Physiology. 2003;285(2 54-2):H687-H692.
  82

• 46.

  2003

  Ming Li; Michael M. Ittmann; David R. Rowley; Anne A. Knowlton; Ajula K. Vaid; Daniel E. Epner

  Glutathione S-transferase pi is upregulated in the stromal compartment of hormone independent prostate cancer

  Prostate. 2003;56(2):98-105.
  8

• 47.

  2003

  A.A. Knowlton; S. Gupta

  HSP60, Bax, and Cardiac Apoptosis

  Cardiovascular Toxicology. 2003;3(3):263-268.
  17

• 48.

  2002

  Y.-H. Wang; A.A. Knowlton; F.-H. Li; S.C. Borkan

  Hsp72 expression enhances survival in adenosine triphosphate-depleted renal epithelial cells

  Cell Stress and Chaperones. 2002;7(2):137-145.
  20

• 49.

  2002

  R.N.M. Cornelussen; A.A. Knowlton

  Heme-oxygenase-1: Versatile sentinel against injury

  Journal of Molecular and Cellular Cardiology. 2002;34(10):1297-1300.
  3

• 50.

  2002

  S.R. Kirchhoff; S. Gupta; A.A. Knowlton

  Cytosolic heat shock protein 60, apoptosis, and myocardial injury

  Circulation. 2002;105(24):2899-2904.
  153

• 51.

  2002

  S. Gupta; A.A. Knowlton

  Cytosolic heat shock protein 60, hypoxia, and apoptosis

  Circulation. 2002;106(21):2727-2733.
  84

• 52.

  2001

  R.N.M. Cornelussen; S. Gupta; A.A. Knowlton

  Regulation of prostaglandin A₁-induced heat shock protein expression in isolated cardiomyocytes

  Journal of Molecular and Cellular Cardiology. 2001;33(8):1447-1454.
  11

• 53.

  2001

  M.D. Howell; J.M. Geraci; A.A. Knowlton

  Congestive heart failure and outpatient risk of venous thromboembolism: A retrospective, case-control study

  Journal of Clinical Epidemiology. 2001;54(8):810-816.
  67

• 54.

  2001

  A.A. Knowlton; Limin Sun

  Heat-shock factor-1, steroid hormones, and regulation of heat-shock protein expression in the heart

  American Journal of Physiology - Heart and Circulatory Physiology. 2001;280(1 49-1):H455-H464.
  78

• 55.

  2001

  J. Chang; A.A. Knowlton; F. Xu; J.S. Wasser

  Activation of the heat shock response: Relationship to energy metabolites. A ³¹P NMR study in rat hearts

  American Journal of Physiology - Heart and Circulatory Physiology. 2001;280(1 49-1):H426-H433.
  13

• 56.

  2001

  A.A. Knowlton

  Mutation of amino acids 566-572 (KKKVLDK) inhibits nuclear accumulation of heat shock protein 72 after heat shock

  Journal of Molecular and Cellular Cardiology. 2001;33(1):49-55.
  5

• 57.

  2001

  Jiang Chang; Jeremy S. Wasser; Richard N.M. Cornelussen; A.A. Knowlton

  Activation of heat-shock factor by stretch-activated channels in rat hearts

  Circulation. 2001;104(2):209-214.
  26

• 58.

  2001

  R.N. Cornelussen; F.A. van Nieuwenhoven; L.H. Snoeckx; A.A. Knowlton

  Presence of heat shock protein 72 in cardiomyocytes after heat stress.

  Circulation. 2001;104(22):E123.
  4

• 59.

  2000

  A.A. Knowlton; M. Grenier; S.R. Kirchhoff; M. Salfity

  Phosphorylation at tyrosine-524 influences nuclear accumulation of HSP72 with heat stress

  American Journal of Physiology - Heart and Circulatory Physiology. 2000;278(6 47-6):H2143-H2149.
  20

• 60.

  2000

  J. Chang; A.A. Knowlton; J.S. Wasser

  Expression of heat shock proteins in turtle and mammal hearts: Relationship to anoxia tolerance

  American Journal of Physiology - Regulatory Integrative and Comparative Physiology. 2000;278(1 47-1):R209-R214.
  33

• 61.

  2000

  L. Sun; J. Chang; S.R. Kirchhoff; A.A. Knowlton

  Activation of HSF and selective increase in heat-shock proteins by acute dexamethasone treatment

  American Journal of Physiology - Heart and Circulatory Physiology. 2000;278(4 47-4):H1091-H1097.
  68

• 62.

  2000

  J.M. Geraci; A.A. Knowlton

  Spironolactone for heart failure: Spiraling out of control

  Chest. 2000;118(6):1522-1523.
  3

• 63.

  1999

  Yihan Wang; Anne A. Knowlton; Thomas G. Christensen; Theodora Shih; Steven C. Borkan

  Prior heat stress inhibits apoptosis in adenosine triphosphate-depleted renal tubular cells

  Kidney International. 1999;55(6):2224-2235.
  49

• 64.

  1999

  A.A. Knowlton

  Mutation of amino acids 246-251 alters nuclear accumulation of human heat shock protein (HSP) 72 with stress, but does not reduce viability

  Journal of Molecular and Cellular Cardiology. 1999;31(3):523-532.
  16

• 65.

  1999

  M.D. Howell; J.M. Geraci; A.A. Knowlton

  Congestive heart failure increases outpatients' risk of venous thromboembolism

  Journal of Investigative Medicine. 1999;47(2):113A.
  0

• 66.

  1998

  Anne A. Knowlton; Samir Kapadia; Guillermo Torre-Amione; Jean-Bernard Durand; Roger Bies; James Young; Douglas L. Mann

  Differential expression of heat shock proteins in normal and failing human hearts

  Journal of Molecular and Cellular Cardiology. 1998;30(4):811-818.
  103

• 67.

  1998

  Masayuki Nakano; Anne A. Knowlton; Ziad Dibbs; Douglas L. Mann

  Tumor necrosis factor-α confers resistance to hypoxic injury in the adult mammalian cardiac myocyte

  Circulation. 1998;97(14):1392-1400.
  99

• 68.

  1997

  Masayuki Nakano; Douglas L. Mann; Anne A. Knowlton

  Blocking the endogenous increase in HSP 72 increases susceptibility to hypoxia and reoxygenation in isolated adult feline cardiocytes

  Circulation. 1997;95(6):1523-1531.
  85

• 69.

  1996

  J. Chang; A.A. Knowlton; J.S. Wasser

  Expression of heat shock proteins in turtle an0 mammalian hearts: Relationship to anoxia tolerance

  FASEB Journal. 1996;10(3):A298.
  1

• 70.

  1996

  A.A. Knowlton; M. Salfity

  Nuclear localization and the heat shock proteins

  Journal of Biosciences. 1996;21(2):123-132.
  25

• 71.

  1996

  Masayuki Nakano; Anne A. Knowlton; Tomoyuki Yokoyama; Werner Lesslauer; Douglas L. Mann

  Tumor necrosis factor-α-induced expression of heat shock protein 72 in adult feline cardiac myocytes

  American Journal of Physiology - Heart and Circulatory Physiology. 1996;270(4 39-4):H1231-H1239.
  59

• 72.

  1995

  A.A. Knowlton

  Current concepts in transcription, translation, and the regulation of gene expression: A primer for the clinician

  Chest. 1995;107(1):241-248.
  1

• 73.

  1995

  J.-Z. Sun; X.-L. Tang; A.A. Knowlton; S.-W. Park; Y. Qiu; R. Bolli

  Late preconditioning against myocardial stunning. An endogenous protective mechanism that confers resistance to postischemic dysfunction 24 h after brief ischemia in conscious pigs

  Journal of Clinical Investigation. 1995;95(1):388-403.
  192

• 74.

  1995

  A.A. Knowlton

  The role of heat shock proteins in the heart

  Journal of Molecular and Cellular Cardiology. 1995;27(1):121-131.
  100

• 75.

  1994

  A.A. Knowlton

  Heat-shock proteins, stress, and the heart

  Annals of the New York Academy of Sciences. 1994;723:128-137.
  19

• 76.

  1992

  A.A. Knowlton; C.M. Connelly; G.M. Romo; W. Mamuya; C.S. Apstein; P. Brecher

  Rapid expression of fibronectin in the rabbit heart after myocardial infarction with and without reperfusion

  Journal of Clinical Investigation. 1992;89(4):1060-1068.
  60

• 77.

  1991

  A.A. Knowlton; P. Brecher; C.S. Apstein

  Rapid expression of heat shock protein in the rabbit after brief cardiac ischemia

  Journal of Clinical Investigation. 1991;87(1):139-147.
  167

• 78.

  1991

  A.A. Knowlton; F.R. Eberli; P. Brecher; G.M. Romo; A. Owen; C.S. Apstein; S. Ngoy

  A single myocardial stretch or decreased systolic fiber shortening stimulates the expression of heat shock protein 70 in the isolated, erythrocyte-perfused rabbit heart

  Journal of Clinical Investigation. 1991;88(6):2018-2025.
  64

• 79.

  1990

  A.A. Knowlton; R.H. Falk

  Paradoxical increase in heart rate before conversion to sinus rhythm in patients with recent-onset atrial fibrillation

  American Journal of Cardiology. 1990;65(13):930-932.
  1

• 80.

  1989

  A.A. Knowlton; C.S. Apstein; R. Saouf; P. Brecher

  Leakage of heart fatty acid binding protein with ischemia and reperfusion in the rat

  Journal of Molecular and Cellular Cardiology. 1989;21(6):577-583.
  24

• 81.

  1989

  A.A. Knowlton; R.E. Burrier; P. Brecher

  Rabbit heart fatty acid-binding protein: Isolation, characterization, and application of a monoclonal antibody

  Circulation Research. 1989;65(4):981-988.
  12

• 82.

  1988

  R.H. Falk; A.A. Knowlton; N.J. Battinelli

  The effect of propranolol and verapamil on external pacing threshold: A placebo-controlled study

  PACE - Pacing and Clinical Electrophysiology. 1988;11(10):1439-1443.
  2

• 83.

  1988

  R.H. Falk; A.A. Knowlton; S. Manaker; E. McAllister; J.L. Stickney

  Verapamil-induced atrial fibrillation

  New England Journal of Medicine. 1988;318(10):640-641.
  3

• 84.

  1988

  S.E. Wiegers; J.F. Plehn; A. Rajail-Khorasani; A.A. Knowlton

  Purulent pericarditis and ventricular pseudoaneurysm in an intravenous drug abuser

  American Heart Journal. 1988;116(6 I):1635-1637.
  5

• 85.

  1987

  R.H. Falk; A.A. Knowlton; S.A. Bernard; N.E. Gotlieb; N.J. Battinelli

  Digoxin for converting recent-onset atrial fibrillation to sinus rhythm. A randomized, double-blinded trial

  Annals of Internal Medicine. 1987;106(4):503-506.
  208

• 86.

  1987

  Rodney N. Falk; Anne A. Knowlton

  Atypical ventricular tachycardia or motion artifact?

  The American Journal of Cardiology. 1987;59(8):924.
  7

• 87.

  1987

  R.H. Falk; A.A. Knowlton

  Is digoxin necessary in converting recent-onset atrial fibrillation?

  Cardiology Board Review. 1987;4(11):99-105.
  0

• 88.

  1986

  A.A. Knowlton; R.H. Falk

  External cardiac pacing during in-hospital cardiac arrest

  American Journal of Cardiology. 1986;57(15):1295-1298.
  19

• 89.

  1986

  A.A. Knowlton; C.M. Connelly; C.S. Apstein

  The effect of fluorocarbon solution on post-myocardial infarction scar tissue strength

  Journal of Applied Cardiology. 1986;1(2):175-180.
  0