Lee-Way Jin

Pathology and Laboratory Medicine

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Lee-Way Jin

• Departments
  Pathology and Laboratory Medicine
  
  

  Current Appointments:

  Prof

  
  
  
Current Appointments:
Prof

H-Index:27

This is a list of publications by this researcher, listed chronologically starting with the most recent first. New publications appear in this list weekly. The source of publications and 'cited by' data for this application is Scopus.

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• 1.

  2012

  Makoto Horiuchi; Izumi Maezawa; Aki Itoh; Kouji Wakayama; Lee-Way Jin; Takayuki Itoh; Charles DeCarli

  Amyloid β1-42 oligomer inhibits myelin sheet formation in vitro

  Neurobiology of Aging. 2012;33(3):499-509.
  4

• 2.

  2012

  Jitka Petrlova; Tamás Kálai; Izumi Maezawa; Robin Altman; Ghimire Harishchandra; Hyun-Seok Hong; Daniel A. Bricarello; Atul N. Parikh; Gary A. Lorigan; Lee-Way Jin; et al.

  The influence of spin-labeled fluorene compounds on the assembly and toxicity of the aβ peptide

  PLoS ONE. 2012;7(4).
  1

• 3.

  2012

  F. Tassone; C.M. Greco; M.R. Hunsaker; A.L. Seritan; R.F. Berman; L.W. Gane; S. Jacquemont; K. Basuta; L.-W. Jin; P.J. Hagerman; et al.

  Neuropathological, clinical and molecular pathology in female fragile X premutation carriers with and without FXTAS

  Genes, Brain and Behavior. 2012;11(5):577-585.
  5

• 4.

  2012

  Giovanni Coppola; Subashchandrabose Chinnathambi; Jason JiYong Lee; Beth A. Dombroski; Matt C. Baker; Alexandra I. Soto-ortolaza; Suzee E. Lee; Eric Klein; Alden Y. Huang; Renee Sears; et al.

  Evidence for a role of the rare p.A152T variant in mapt in increasing the risk for FTD-spectrum and Alzheimer's diseases

  Human Molecular Genetics. 2012;21(15):3500-3512.
  4

• 5.

  2012

  Izumi Maezawa; Marco Calafiore; Heike Wulff; Lee-Way Jin

  Does microglial dysfunction play a role in autism and Rett syndrome?

  Neuron Glia Biology. 2012;7(1):85-97.
  5

• 6.

  2012

  Nanette C. Joyce; Björn Oskarsson; Lee-Way Jin

  Muscle biopsy evaluation in neuromuscular disorders

  Physical Medicine and Rehabilitation Clinics of North America. 2012;23(3):609-631.
  0

• 7.

  2012

  Christopher C. Zimmer; Lifang Shi; Yiping Shih; Jieren Li; Leeway Jin; Suhao Lo; Gangyu Liu

  F-Actin reassembly during focal adhesion impacts single cell mechanics and nanoscale membrane structure

  Science China Chemistry. 2012;55(9):1922-1930.
  0

• 8.

  2012

  Laxman Pokhrel; Izumi Maezawa; Thi D. T. Nguyen; Kyeong-Ok Chang; Lee-Way Jin; Duy H. Hua

  Inhibition of Acyl-CoA: Cholesterol acyltransferase (ACAT), overexpression of cholesterol transporter gene, and protection of amyloid β (Aβ) oligomers-induced neuronal cell death by tricyclic pyrone molecules

  Journal of Medicinal Chemistry. 2012;55(20):8969-8973.
  0

• 9.

  2012

  David C. Whitcomb; Jessica LaRusch; Alyssa M. Krasinskas; Lambertus Klei; Jill P. Smith; Randall E. Brand; John P. Neoptolemos; Markus M. Lerch; Matt Tector; Bimaljit S. Sandhu; et al.

  Common genetic variants in the CLDN2 and PRSS1-PRSS2 loci alter risk for alcohol-related and sporadic pancreatitis

  Nature Genetics. 2012;44(12):1349-1354.
  1

• 10.

  2012

  Lee-Way Jin

  Microglia in Alzheimer's disease

  International Journal of Alzheimer's Disease. 2012.
  0

• 11.

  2011

  Jitka Petrlova; Hyun-Seok Hong; Daniel A. Bricarello; Ghimire Harishchandra; Gary A. Lorigan; Lee-Way Jin; John C. Voss

  A differential association of Apolipoprotein E isoforms with the amyloid-β oligomer in solution

  Proteins: Structure, Function and Bioinformatics. 2011;79(2):402-416.
  7

• 12.

  2011

  Jie Li; Ruiwu Liu; Kit S. Lam; Lee-Way Jin; Yong Duan

  Alzheimer's disease drug candidates stabilize A-β protein native structure by interacting with the hydrophobic core

  Biophysical Journal. 2011;100(4):1076-1082.
  7

• 13.

  2011

  Izumi Maezawa; Pavel I. Zimin; Heike Wulff; Lee-Way Jin

  Amyloid-β protein oligomer at low nanomolar concentrations activates microglia and induces microglial neurotoxicity

  Journal of Biological Chemistry. 2011;286(5):3693-3706.
  29

• 14.

  2011

  Adam C. Naj; Gyungah Jun; Gary W. Beecham; Li-San Wang; Badri Narayan Vardarajan; Jacqueline Buros; Paul J. Gallins; Joseph D. Buxbaum; Gail P. Jarvik; Paul K. Crane; et al.

  Common variants at MS4A4/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset Alzheimer's disease

  Nature Genetics. 2011;43(5):436-443.
  195

• 15.

  2011

  Claudia M. Greco; Celestine S. Navarro; Michael R. Hunsaker; Izumi Maezawa; John F. Shuler; Flora Tassone; Mary Delany; Jacky W. Au; Robert F. Berman; Lee-Way Jin; et al.

  Neuropathologic features in the hippocampus and cerebellum of three older men with fragile X syndrome

  Molecular Autism. 2011;2(1).
  11

• 16.

  2011

  Katrina Gwinn; Michael J. Devine; Lee-Way Jin; Janel Johnson; Thomas Bird; Manfred Muenter; Cheryl Waters; Charles H. Adler; Richard Caselli; Henry Houlden; et al.

  Clinical features, with video documentation, of the original familial lewy body parkinsonism caused by α-synuclein triplication (Iowa kindred)

  Movement Disorders. 2011;26(11):2134-2136.
  5

• 17.

  2010

  Izumi Maezawa; Lee-Way Jin

  Rett syndrome microglia damage dendrites and synapses by the elevated release of glutamate

  Journal of Neuroscience. 2010;30(15):5346-5356.
  60

• 18.

  2010

  Kun-Ju Lin; Wen-Chuin Hsu; Ing-Tsung Hsiao; Shiaw-Pyng Wey; Lee-Way Jin; Daniel Skovronsky; Yau-Yau Wai; Hsiu-Ping Chang; Chuan-Wei Lo; Cheng Hsiang Yao; et al.

  Whole-body biodistribution and brain PET imaging with [¹⁸F]AV-45, a novel amyloid imaging agent - a pilot study

  Nuclear Medicine and Biology. 2010;37(4):497-508.
  40

• 19.

  2010

  Hyun-Seok Hong; Izumi Maezawa; Madhu Budamagunta; Sandeep Rana; Aibin Shi; Robert Vassar; Ruiwu Liu; Kit S. Lam; R. Holland Cheng; Duy H. Hua; et al.

  Candidate anti-Aβ fluorene compounds selected from analogs of amyloid imaging agents

  Neurobiology of Aging. 2010;31(10):1690-1699.
  5

• 20.

  2010

  Valentin Lulevich; Christopher C. Zimmer; Hyun-Seok Hong; Lee-Way Jin; Gang-Yu Liu

  Single-cell mechanics provides a sensitive and quantitative means for probing amyloid-β peptide and neuronal cell interactions

  Proceedings of the National Academy of Sciences of the United States of America. 2010;107(31):13872-13877.
  12

• 21.

  2009

  Sandeep Rana; Hyun-Seok Hong; Lydia Barrigan; Lee-Way Jin; Duy H. Hua

  Syntheses of tricyclic pyrones and pyridinones and protection of Aβ-peptide induced MC65 neuronal cell death

  Bioorganic and Medicinal Chemistry Letters. 2009;19(3):670-674.
  3

• 22.

  2009

  Hyun-Seok Hong; Sandeep Rana; Lydia Barrigan; Aibin Shi; Yi Zhang; Feimeng Zhou; Lee-Way Jin; Duy H. Hua

  Inhibition of Alzheimer's amyloid toxicity with a tricyclic pyrone molecule in vitro and in vivo

  Journal of Neurochemistry. 2009;108(4):1097-1108.
  27

• 23.

  2009

  Izumi Maezawa; Susan Swanberg; Danielle Harvey; Janine M LaSalle; Lee-Way Jin

  Rett syndrome astrocytes are abnormal and spread MeCP2 deficiency through gap junctions

  Journal of Neuroscience. 2009;29(16):5051-5061.
  68

• 24.

  2008

  Izumi Maezawa; Hyun-Seok Hong; Ruiwu Liu; Chun-Yi Wu; R. Holland Cheng; Mei-Ping Kung; Hank F. Kung; Kit S. Lam; Salvatore Oddo; Frank M. LaFerla; et al.

  Congo red and thioflavin-T analogs detect Aβ oligomers

  Journal of Neurochemistry. 2008;104(2):457-468.
  77

• 25.

  2007

  Michael J. House; Timothy G. St. Pierre; Kris V. Kowdley; Thomas Montine; James Connor; John Beard; Jose Berger; Narendra Siddaiah; Eric Shankland; Lee-Way Jin

  Correlation of proton transverse relaxation rates (R₂) with iron concentrations in postmortem brain tissue from Alzheimer's disease patients

  Magnetic Resonance in Medicine. 2007;57(1):172-180.
  31

• 26.

  2007

  Hyun-Seok Hong; Izumi Maezawa; Nianhuan Yao; Bailing Xu; Ruben Diaz-Avalos; Sandeep Rana; Duy H. Hua; R. Holland Cheng; Kit S. Lam; et al.

  Combining the rapid MTT formazan exocytosis assay and the MC65 protection assay led to the discovery of carbazole analogs as small molecule inhibitors of Aβ oligomer-induced cytotoxicity

  Brain Research. 2007;1130(1):223-234.
  23

• 27.

  2007

  Rajesh Chandra; Shunichi Oya; Mei-Ping Kung; Catherine Hou; Lee-Way Jin; Hank F. Kung

  New diphenylacetylenes as probes for positron emission tomographic imaging of amyloid plaques

  Journal of Medicinal Chemistry. 2007;50(10):2415-2423.
  18

• 28.

  2007

  Wenchao Qu; Mei-Ping Kung; Catherine Hou; Lee-Way Jin; Hank F. Kung

  Radioiodinated aza-diphenylacetylenes as potential SPECT imaging agents for β-amyloid plaque detection

  Bioorganic and Medicinal Chemistry Letters. 2007;17(13):3581-3584.
  9

• 29.

  2007

  Jens O. Lagerstedt; Giorgio Cavigiolio; Linda M. Roberts; Hyun-Seok Hong; Lee-Way Jin; Paul G. FitzGerald; Michael N. Oda; John C. Voss

  Mapping the structural transition in an amyloidogenic apolipoprotein A-I

  Biochemistry. 2007;46(34):9693-9699.
  13

• 30.

  2006

  B. Bu; P. Ashwood; D. Harvey; I.B. King; J.Van de Water; L.-W. Jin

  Fatty acid compositions of red blood cell phospholipids in children with autism

  Prostaglandins Leukotrienes and Essential Fatty Acids. 2006;74(4):215-221.
  21

• 31.

  2006

  Werner Kaminksy; Lee-Way Jin; Steven Powell; Izumi Maezawa; Kacey Claborn; Charles Branham; Bart Kahr

  Polarimetric imaging of amyloid

  Micron. 2006;37(4):324-338.
  14

• 32.

  2006

  Izumi Maezawa; Hyun-Seok Hong; Hui-Chuan Wu; Srinivas K. Battina; Sandeep Rana; Takeo Iwamoto; Gary A. Radke; Erik Pettersson; George M. Martin; Duy H. Hua; et al.

  A novel tricyclic pyrone compound ameliorates cell death associated with intracellular amyloid-β oligomeric complexes

  Journal of Neurochemistry. 2006;98(1):57-67.
  37

• 33.

  2006

  Erin M. Ramos; Ming-Tesh Lin; Eric B. Larson; Izumi Maezawa; Li-Hui Tseng; Karen L. Edwards; Gerard D. Schellenberg; John A. Hansen; Walter A. Kukull; Lee-Way Jin

  Tumor necrosis factor α and interleukin 10 promoter region polymorphisms and risk of late-onset Alzheimer disease

  Archives of Neurology. 2006;63(8):1165-1169.
  37

• 34.

  2005

  Simona Vuletic; Elaine R. Peskind; Santica M. Marcovina; Joseph F. Quinn; Marian C. Cheung; Hal Kennedy; Jeffrey A. Kaye; Lee-Way Jin; John J. Albers

  Reduced CSF PLTP activity in Alzheimer's disease and other neurologic diseases; PLTP induces ApoE secretion in primary human astrocytes in vitro

  Journal of Neuroscience Research. 2005;80(3):406-413.
  23

• 35.

  2004

  Baiping Wang; Qubai Hu; Mark G. Hearn; Kimiko Shimizu; Carol B. Ware; Dennis H. Liggitt; Lee-Way Jin; Bethany H. Cool; Daniel R. Storm; George M. Martin

  Isoform-Specific Knockout of FE65 Leads to Impaired Learning and Memory

  Journal of Neuroscience Research. 2004;75(1):12-24.
  40

• 36.

  2004

  Izumi Maezawa; Lee-Way Jin; Randall L. Woltjer; Nobuyo Maeda; George M. Martin; Thomas J. Montine; Kathleen S. Montine

  Apolipoprotein E isoforms and apolipoprotein AI protect from amyloid precursor protein carboxy terminal fragment-associated cytotoxicity

  Journal of Neurochemistry. 2004;91(6):1312-1321.
  27

• 37.

  2004

  Bryce L. Sopher; Patrick S. Thomas Jr.; Michelle A. Lafevre-Bernt; Ida E. Holm; Scott A. Wilke; Carol B. Ware; Lee-Way Jin; Randell T. Libby; Lisa M. Ellerby; Albert R. La Spada

  Androgen receptor YAC transgenic mice recapitulate SBMA motor neuronopathy and implicate VEGF164 in the motor neuron degeneration

  Neuron. 2004;41(5):687-699.
  87

• 38.

  2004

  Lee-Way Jin; Izumi Maezawa; Inez Vincent; Thomas Bird

  Intracellular Accumulation of Amyloidogenic Fragments of Amyloid-β Precursor Protein in Neurons with Niemann-Pick Type C Defects Is Associated with Endosomal Abnormalities

  American Journal of Pathology. 2004;164(3):975-985.
  89

• 39.

  2003

  David G. Cook; James B. Leverenz; Pamela J. McMillan; J. Jacob Kulstad; Sasha Ericksen; Richard A. Roth; Gerard D. Schellenberg; Lee-Way Jin; Kristina S. Kovacina; et al.

  Reduced hippocampal insulin-degrading enzyme in late-onset Alzheimer's disease is associated with the apolipoprotein E-ε4 allele

  American Journal of Pathology. 2003;162(1):313-319.
  134

• 40.

  2003

  Jochen Brich; Feng-Shiun Shie; Brian W. Howell; Renhua Li; Katalin Tus; Edward K. Wakeland; Lee-Way Jin; Marc Mumby; Gary Churchill; Joachim Herz; et al.

  Genetic modulation of tau phosphorylation in the mouse

  Journal of Neuroscience. 2003;23(1):187-192.
  42

• 41.

  2003

  Feng-Shiun Shie; Renée C. LeBoeur; Lee-Way Jin

  Early intraneuronal Aβ deposition in the hippocampus of APP transgenic mice

  NeuroReport. 2003;14(1):123-129.
  58

• 42.

  2003

  Duy H. Hua; Xiaodong Huang; Masafumi Tamura; Yi Chen; Melissa Woltkamp; Lee-Way Jin; Elisabeth M. Perchellet; Jean-Pierre Perchellet; Peter K. Chiang; Ichiji Namatame; et al.

  Syntheses and bioactivities of tricyclic pyrones

  Tetrahedron. 2003;59(26):4795-4803.
  19

• 43.

  2003

  Simona Vuletic; Lee-Way Jin; Santica M. Marcovina; Elaine R. Peskind; Thomas Möller; John J. Albers

  Widespread distribution of PLTP in human CNS: Evidence for PLTP synthesis by glia and neurons, and increased levels in Alzheimer's disease

  Journal of Lipid Research. 2003;44(6):1113-1123.
  24

• 44.

  2003

  Lee-Way Jin; Kacey A. Claborn; Miki Kurimoto; Morten A. Geday; Izumi Maezawa; Faranak Sohraby; Marcus Estrada; Werner Kaminksy; Bart Kahr

  Imaging linear birefringence and dichroism in cerebral amyloid pathologies

  Proceedings of the National Academy of Sciences of the United States of America. 2003;100(26):15294-15298.
  96

• 45.

  2003

  Mei-Ping Kung; Zhi-Ping Zhuang; Catherine Hou; Lee-Way Jin; Hank F. Kung

  Characterization of Radioiodinated Ligand Binding to Amyloid β Plaques

  Journal of Molecular Neuroscience. 2003;20(3):249-253.
  15

• 46.

  2002

  Miki Kurimoto; Beat Müller; Werner Kaminsky; Bart Kahr; Lee-Way Jin

  Dyeing crystals to dyeing tissues: Congo red in anisotropic media

  Molecular Crystals and Liquid Crystals Science and Technology Section A: Molecular Crystals and Liquid Crystals. 2002;389(PART I):1-9.
  4

• 47.

  2002

  Jin Xu; Shyan-Yuan Kao; Frank J.S. Lee; Weihong Song; Lee-Way Jin; Bruce A. Yankner

  Dopamine-dependent neurotoxicity of α-synuclein: A mechanism for selective neurodegeneration in Parkinson disease

  Nature Medicine. 2002;8(6):600-606.
  389

• 48.

  2002

  Izumi Maezawa; Baiping Wang; Qubai Hu; George M. Martin; Lee-Way Jin; Junko Oshima

  Alterations of chaperone protein expression in presenilin mutant neurons in response to glutamate excitotoxicity

  Pathology International. 2002;52(9):551-554.
  2

• 49.

  2002

  L.-W. Jin; D.H. Hua; F.-S. Shie; I. Maezawa; B. Sopher; G.M. Martin

  Novel tricyclic pyrone compounds prevent intracellular APP C99-induced cell death

  Journal of Molecular Neuroscience. 2002;19(1-2):57-61.
  21

• 50.

  2002

  Bitao Bu; Hans Klunemann; Kinuko Suzuki; Jin Li; Thomas Bird; Lee-Way Jin; Inez Vincent

  Niemann-Pick disease type C yields possible clue for why cerebellar neurons do not form neurofibrillary tangles

  Neurobiology of Disease. 2002;11(2):285-297.
  42

• 51.

  2002

  Feng-Shiun Shie; Lee-Way Jin; David G. Cook; James B. Leverenz; Renée C. LeBoeuf

  Diet-induced hypercholesterolemia enhances brain Aβ accumulation in transgenic mice

  NeuroReport. 2002;13(4):455-459.
  117

• 52.

  2001

  A. Tomashevski; J. Husseman; L.-W. Jin; D. Nochlin; I. Vincent

  Constitutive wee1 activity in adult brain neurons with M phase-type alterations in Alzheimer neurodegeneration

  Journal of Alzheimer's Disease. 2001;3(2):195-207.
  13

• 53.

  2001

  Jacob W. Husseman; Janice L. Hallows; David B. Bregman; James B. Leverenz; David Nochlin; Lee-Way Jin; Inez Vincent

  Hyperphosphorylation of RNA polymerase II and reduced neuronal RNA levels precede neurofibrillary tangles in Alzheimer disease

  Journal of Neuropathology and Experimental Neurology. 2001;60(12):1219-1232.
  13

• 54.

  2001

  I. Vincent; B. Bu; K. Hudson; J. Husseman; D. Nochlin; L.-W. Jin

  Constitutive Cdc25B tyrosine phosphatase activity in adult brain neurons with M phase-type alterations in Alzheimer's disease

  Neuroscience. 2001;105(3):639-650.
  34

• 55.

  2000

  X.-L. Ding; J. Husseman; A. Tomashevski; D. Nochlin; L.-W. Jin; I. Vincent

  The cell cycle Cdc25A tyrosine phosphatase is activated in degenerating postmitotic neurons in Alzheimer's disease

  American Journal of Pathology. 2000;157(6):1983-1990.
  53

• 56.

  2000

  Qubai Hu; Lee-Way Jin; Marilyn Y. Starbuck; George M. Martin

  Broadly altered expression of the mRNA isoforms of FE65, a facilitator of beta amyloidogenesis, in Alzheimer cerebellum and other brain regions

  Journal of Neuroscience Research. 2000;60(1):73-86.
  17

• 57.

  1999

  Qub ai Hu; Mark G. Hearn; Lee-Way Jin; Steven L. Bressler; George M. Martin

  Alternatively spliced isoforms of FE65 serve as neuron-specific and non- neuronal markers

  Journal of Neuroscience Research. 1999;58(5):632-640.
  19

• 58.

  1999

  H.V. Nguyen; L.W. Jin

  Possible use of sulfated glycosaminoglycans in making a cell culture model of neurofibrillary tangle formation

  Journal of Investigative Medicine. 1999;47(2):66A.
  0

• 59.

  1998

  Lee-Way Jin; Mark G. Hearn; Charles E. Ogburn; Ngocthao Dang; David Nochlin; Warren C. Ladiges; George M. Martin

  Transgenic mice over-expressing the C-99 fragment of βPP with an α- secretase site mutation develop a myopathy similar to human inclusion body myositis

  American Journal of Pathology. 1998;153(6):1679-1686.
  57

• 60.

  1996

  L.-W. Jin; E. Masliah; D. Iimoto; R. Deteresa; M. Mallory; M. Sundsmo; N. Mori; A. Sobel; T. Saitoh

  Neurofibrillary tangle-associated alteration of stathmin in Alzheimer's disease

  Neurobiology of Aging. 1996;17(3):331-341.
  18

• 61.

  1995

  Jin Lee-Way; T. Saitoh

  Changes in protein kinases in brain aging and Alzheimer's disease: Implications for drug therapy

  Drugs and Aging. 1995;6(2):136-149.
  48

• 62.

  1994

  H. Ninomiya; J.-M. Roch; L.-W. Jin; T. Saitoh

  Secreted form of amyloid β/A4 protein precursor (APP) binds to two distinct APP binding sites on rat B103 neuron-like cells through two different domains, but only one site is involved in neuritotropic activity

  Journal of Neurochemistry. 1994;63(2):495-500.
  36

• 63.

  1994

  Lee-Way Jin; Haruaki Ninomiya; Jean-Marc Roch; David Schubert; Eliezer Masliah; Deborah A. C. Otero; Tsunao Saitoh

  Peptides containing the RERMS sequence of amyloid β/A4 protein precursor bind cell surface and promote neurite extension

  Journal of Neuroscience. 1994;14(9):5461-5470.
  127

• 64.

  1993

  J.-M. Roch; L.-W. Jin; H. Ninomiya; D. Schubert; T. Saitoh

  Biologically active domain of the secreted form of the amyloid β/A4 protein precursor

  Annals of the New York Academy of Sciences. 1993;695:149-157.
  14

• 65.

  1992

  L.-W. Jin; K. Inaba; T. Saitoh

  The involvement of protein kinase C in activation-induced cell death in T- cell hybridoma

  Cellular Immunology. 1992;144(1):217-227.
  18

• 66.

  1991

  T. Saitoh; E. Masliah; L.-W. Jin; G.M. Cole; T. Wieloch; I.P. Shapiro

  Protein kinases and phosphorylation in neurologic disorders and cell death

  Laboratory Investigation. 1991;64(5):596-616.
  43

• 67.

  1989

  D. Schubert; L-W. Jin; T. Saitoh; Greg Cole

  The regulation of amyloid β protein precursor secretion and its modulatory role in cell adhesion

  Neuron. 1989;3(6):689-694.
  161