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Ronald S. Flannagan; Rene E. Harrison; Christopher M. Yip; Khuloud Jaqaman; Sergio Grinstein(Profiled Author: Khuloud Jaqaman)
Journal of Cell Biology. 2010;191(6):1205-1218.Abstract
Binding of ligands by immunoreceptors is thought to be a passive, stochastic process. Contrary to this notion, we found that binding of IgG-opsonized particles by Fcγ receptors was inhibited in macrophages, dendritic and microglial cells by agents that interfere with actin assembly or disassembly. Changes in the lateral mobility of the receptors - assessed by single-particle tracking - or in the microelasticity of the membrane - determined by atomic-force microscopy - could not account for the effects of actin disruption on particle binding. Instead, we found that the macrophages contact their targets by actively extending actin-rich structures. Formation of these protrusions is driven by Rac and requires phosphatidylinositol 4,5-bisphosphate and phosphatidylinositol 3,4,5-trisphosphate. Capture of C3bi-opsonized as well as unopsonized targets by macrophages was also dependent on actin. Thus, phagocytes continuously probe their environment for foreign particles in a manner akin to the constitutive sampling of the fluid milieu by dendritic cells. Active probing by phagocytes is most important when confronted by scarcely opsonized and/or highly mobile targets. © 2010 Flannagan et al.
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