Scopus Publication Detail
The publication detail shows the title, authors (with indicators showing other profiled authors), information on the publishing organization, abstract and a link to the article in Scopus. This abstract is what is used to create the fingerprint of the publication.
Kathryn T. Applegate; Sebastien Besson; Alexandre Matov; Maria H. Bagonis; Khuloud Jaqaman; Gaudenz Danuser(Profiled Authors: Gaudenz Danuser; Khuloud Jaqaman)
Journal of Structural Biology. 2011;176(2):168-184.Abstract
Here we introduce plusTipTracker, a Matlab-based open source software package that combines automated tracking, data analysis, and visualization tools for movies of fluorescently-labeled microtubule (MT) plus end binding proteins (+TIPs). Although +TIPs mark only phases of MT growth, the plusTipTracker software allows inference of additional MT dynamics, including phases of pause and shrinkage, by linking collinear, sequential growth tracks. The algorithm underlying the reconstruction of full MT trajectories relies on the spatially and temporally global tracking framework described in Jaqaman et al. (2008). Post-processing of track populations yields a wealth of quantitative phenotypic information about MT network architecture that can be explored using several visualization modalities and bioinformatics tools included in plusTipTracker. Graphical user interfaces enable novice Matlab users to track thousands of MTs in minutes. In this paper, we describe the algorithms used by plusTipTracker and show how the package can be used to study regional differences in the relative proportion of MT subpopulations within a single cell. The strategy of grouping +TIP growth tracks for the analysis of MT dynamics has been introduced before (Matov et al., 2010). The numerical methods and analytical functionality incorporated in plusTipTracker substantially advance this previous work in terms of flexibility and robustness. To illustrate the enhanced performance of the new software we thus compare computer-assembled +TIP-marked trajectories to manually-traced MT trajectories from the same movie used in Matov et al. (2010). © 2011 Elsevier Inc.
This section shows information related to the publication - computed using the fingerprint of the publication - including related publications, related experts with fingerprints representing significant amounts of overlap between their fingerprint and this publication. The red dots indicate whether those experts or terms appear within the publication, thereby showing potential and actual connections.
Alexandre Matov; Kathryn Applegate; Praveen Kumar; Claudio Thoma; Wilhelm Krek; Gaudenz Danuser; Torsten WittmannNature Methods. 2010;7(9):761-768.
Gaudenz DanuserNature methods. 2014;11(3):220.
Claudio R. Thoma; Alexandre Matov; Katrin L. Gutbrodt; Christian R. Hoerner; Zlatko Smole; Wilhelm Krek; Gaudenz DanuserJournal of Cell Biology. 2010;190(6):991-1003.
Appears in this Document