Scopus Publication Detail
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Li-Min Chua; Mei-Li Lim; Pey-Rou Chong; Ze Ping Hu; Nam Sang Cheung; Boon-Seng Wong(Profiled Author: Zeping Hu)
Journal of Alzheimer's Disease. 2012;29(4):783-791.Abstract
Reduced glucose utilization is likely to precede the onset of cognitive deficits in Alzheimer's disease (AD). Similar aberrant glucose metabolism can also be detected in the brain of several AD mouse models. Although the cause of this metabolic defect is not well understood, it could be related to impaired insulin signaling that is increasingly being reported in AD brain. However, the temporal relationship between insulin impairment and amyloid-β (Aβ) biogenesis is unclear. In this study using female AβPPsw/PS1ΔE9 mice, we found that the level of Aβ
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