Scopus Publication Detail
The publication detail shows the title, authors (with indicators showing other profiled authors), information on the publishing organization, abstract and a link to the article in Scopus. This abstract is what is used to create the fingerprint of the publication.
Jian Chen; Yanjiao Li; Tzong-Shiue Yu; Renée M. McKay; Dennis K. Burns; Steven G. Kernie; Luis F. Parada(Profiled Authors: Dennis K Burns; Renee M McKay; Luis F Parada)
Glioblastoma multiforme is the most common primary malignant brain tumour, with a median survival of about one year. This poor prognosis is due to therapeutic resistance and tumour recurrence after surgical removal. Precisely how recurrence occurs is unknown. Using a genetically engineered mouse model of glioma, here we identify a subset of endogenous tumour cells that are the source of new tumour cells after the drug temozolomide (TMZ) is administered to transiently arrest tumour growth. A nestin-δTK-IRES-GFP (Nes-δTK-GFP) transgene that labels quiescent subventricular zone adult neural stem cells also labels a subset of endogenous glioma tumour cells. On arrest of tumour cell proliferation with TMZ, pulse-chase experiments demonstrate a tumour re-growth cell hierarchy originating with the Nes-δTK-GFP transgene subpopulation. Ablation of the GFP + cells with chronic ganciclovir administration significantly arrested tumour growth, and combined TMZ and ganciclovir treatment impeded tumour development. Thus, a relatively quiescent subset of endogenous glioma cells, with properties similar to those proposed for cancer stem cells, is responsible for sustaining long-term tumour growth through the production of transient populations of highly proliferative cells. © 2012 Macmillan Publishers Limited. All rights reserved.
This section shows information related to the publication - computed using the fingerprint of the publication - including related publications, related experts with fingerprints representing significant amounts of overlap between their fingerprint and this publication. The red dots indicate whether those experts or terms appear within the publication, thereby showing potential and actual connections.
Woo-Ping Ge; Atsushi Miyawaki; Fred H. Gage; Yuh Nung Jan; Lily Yeh JanNature. 2012;484(7394):376-380.
John N. Weinstein; Rehan Akbani; Bradley M. Broom; Wenyi Wang; Roeland G. W. Verhaak; David McConkey; Seth Lerner; Margaret Morgan; Chad J. Creighton; Carolyn Smith; et al.Nature. 2014;507(7492):315-322.
Jenny Hsieh; Jay W. SchneiderScience. 2013;340(6127):1534-1535.
Appears in this Document