Scopus Publication Detail
The publication detail shows the title, authors (with indicators showing other profiled authors), information on the publishing organization, abstract and a link to the article in Scopus. This abstract is what is used to create the fingerprint of the publication.
P. Chen; X. Tu; F. Akdemir; S.K. Chew; A. Rothenfluh; J.M. Abrams(Profiled Authors: John M Abrams; Adrian Rothenfluh)
Cell Death and Differentiation. 2012;19(10):1655-1663.Abstract
Heavy alcohol consumption provokes an array of degenerative pathologies but the signals that couple alcohol exposure to regulated forms of cell death are poorly understood. Using Drosophila as a model, we genetically establish that the severity of ethanol challenge dictates the type of death that occurs. In contrast to responses seen under acute exposure, cytotoxic responses to milder challenges required gene encoding components of the apoptosome, Dronc and Dark. We conducted a genome-wide RNAi screen to capture targets that specifically mediate ethanol-induced cell death. One effector, Drat, encodes a novel protein that contains an ADH domain but lacks essential residues in the catalytic site. In cultured cells and neurons in vivo, depletion of Drat conferred protection from alcohol-induced apoptosis. Adults mutated for Drat showed both improved survival and enhanced propensities toward sedation after alcohol challenge. Together, these findings highlight novel effectors that support regulated cell death incited by alcohol stress in vitro and in vivo. © 2012 Macmillan Publishers Limited All rights reserved.
This section shows information related to the publication - computed using the fingerprint of the publication - including related publications, related experts with fingerprints representing significant amounts of overlap between their fingerprint and this publication. The red dots indicate whether those experts or terms appear within the publication, thereby showing potential and actual connections.
Su Kit Chew; Po Chen; Nichole Link; Kathleen A. Galindo; Kristi Pogue; John M. AbramsNature. 2009;460(7251):123-127.
Alejandro D'Brot; Po Chen; Mahesh Vaishnav; Shujun Yuan; Christopher W. Akey; John M. AbramsGenes and Development. 2013;27(15):1650-1655.
Jeanne S. Peterson; B. Paige Bass; Deborah Jue; Antony Rodriguez; John M. Abrams; Kimberly McCallGenesis. 2007;45(6):396-404.
Appears in this Document