Scopus Publication Detail
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Christopher Y. Lu; Pamela D. Winterberg; Jianlin Chen; John R. Hartono(Profiled Author: Christopher Y Lu)
Pediatric Nephrology. 2012;27(10):1847-1854.Abstract
Ischemic acute kidney injury (AKI) contributes to considerable morbidity and mortality in hospitalized patients and can contribute to rejection during kidney transplantation. Maladaptive immune responses can exacerbate injury, and targeting these responses holds promise as therapy for AKI. In the last decade, a number of molecules and receptors were identified in the innate immune response to ischemia-reperfusion injury. This review primarily focuses on one pathway that leads to maladaptive inflammation: toll-like receptor 4 (TLR4) and one of its ligands, high mobility group box protein 1 (HMGB1). The temporal-spatial roles and potential therapeutics targeting this particular receptor-ligand interaction are also explored. © IPNA 2012.
This section shows information related to the publication - computed using the fingerprint of the publication - including related publications, related experts with fingerprints representing significant amounts of overlap between their fingerprint and this publication. The red dots indicate whether those experts or terms appear within the publication, thereby showing potential and actual connections.
Jianlin Chen; Reji John; James A. Richardson; John M. Shelton; Xin J. Zhou; Yanxia Wang; Qing Qing Wu; John R. Hartono; Pamela D. Winterberg; Christopher Y. LuKidney International. 2011;79(3):288-299.
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