Scopus Publication Detail
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Subhash Banerjee; Hao Xu; Eric Fuh; Kytai T. Nguyen; Joseph A. Garcia; Emmanouil S. Brilakis; Deepak L. Bhatt(Profiled Authors: Subhash Banerjee; Emmanouil S Brilakis; Joseph A Garcia; Hao Xu)
Background: Vascular stent coverage by endothelial cells, derived from endothelial progenitor cells (EPC) is considered a surrogate for healing. However, the effects of antiproliferative drugs used in current drug-eluting stents (DES) on EPC proliferative and antithrombotic function remains poorly defined. Method and results: Herein, we studied and compared the in vitro and in vivo effects of four antiproliferative drugs - paclitaxel, sirolimus, everolimus, and zotarolimus on several EPC properties including colony forming units (CFU), cell proliferation, apoptosis, antithrombotic and prothrombotic gene expression and nitric oxide (NO) as well as prostacyclin (PGI
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