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Oxygenation in cervical cancer and normal uterine cervix assessed using blood oxygenation level-dependent (BOLD) MRI at 3T
Rami R. Hallac; Yao Ding; Qing Yuan; Roderick W. Mccoll; Jayanthi Lea; Robert D. Sims; Paul T. Weatherall; Ralph P. Mason(Profiled Authors: Jayanthi S Lea; Ralph P Mason; Roderick W McColl; Paul T Weatherall; Qing Yuan)
NMR in Biomedicine. 2012;25(12):1321-1330.Abstract
Hypoxia is reported to be a biomarker for poor prognosis in cervical cancer. However, a practical noninvasive method is needed for the routine clinical evaluation of tumor hypoxia. This study examined the potential use of blood oxygenation level-dependent (BOLD) contrast MRI as a noninvasive technique to assess tumor vascular oxygenation at 3T. Following Institutional Review Board-approved informed consent and in compliance with the Health Insurance Portability and Accountability Act, successful results were achieved in nine patients with locally advanced cervical cancer [International Federation of Gynecology and Obstetrics (FIGO) stage IIA to IVA] and three normal volunteers. In the first four patients, dynamic T
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