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International Journal of Radiation Oncology Biology Physics. 2012;84(4):894-901.Abstract
Purpose: To evaluate the effects of breast size on dose-volume histogram parameters and clinical toxicity in whole-breast hypofractionated radiation therapy using intensity modulated radiation therapy (IMRT). Materials and Methods: In this retrospective study, all patients undergoing breast-conserving therapy between 2005 and 2009 were screened, and qualifying consecutive patients were included in 1 of 2 cohorts: Large-breasted patients (chest wall separation >25 cm or planning target volume [PTV] >1500 cm
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