Scopus Publication Detail
The publication detail shows the title, authors (with indicators showing other profiled authors), information on the publishing organization, abstract and a link to the article in Scopus. This abstract is what is used to create the fingerprint of the publication.
Ende Pan; Nathaniel W. Oswald; Aaron G. Legako; Janie M. Life; Bruce A. Posner; John B. MacMillan(Profiled Authors: John B MacMillan; Bruce A Posner)
Chemical Science. 2013;4(1):482-488.Abstract
Ammosamides E-F (1-2), are amidine analogs of the ammosamide family of alkaloids isolated from a marine-derived Streptomyces variabilis. Further studies with S. variabilis revealed a variety of aryl and alkyl amines added into the fermentation media could be efficiently incorporated into the ammosamide framework to generate a library of precursor-directed amidine analogs, ammosamides G-P (9-18). We demonstrate that the amines are introduced via non-enzymatic addition to the iminium ion of ammosamide C. Biological evaluation of the amidine analogs against quinone reductase 2 (QR2) showed low nM potency for a number of analogs. When tested for in vivo activity against a panel of non-small cell lung cancer (NSCLC) cell-lines there was a clear increase in potency by incorporation of lipophilic alkylamines, with the most potent compounds having sub μM IC
This section shows information related to the publication - computed using the fingerprint of the publication - including related publications, related experts with fingerprints representing significant amounts of overlap between their fingerprint and this publication. The red dots indicate whether those experts or terms appear within the publication, thereby showing potential and actual connections.
Shanrong Zhang; Kejin Zhou; Gang Huang; Masaya Takahashi; A. Dean Sherry; Jinming GaoChemical Communications. 2013;49(57):6418-6420.
Subrata Patra; Brittany Kozura; Adela Y.-T. Huang; Alan E. Enciso; Xiankai Sun; Jer-Tsong Hsieh; Chai-Lin Kao; Hui-Ting Chen; Eric E. SimanekOrganic Letters. 2013;15(15):3808-3811.
Hongli Bao; Liela Bayeh; Uttam TambarSynlett. 2013;24(18):2459-2463.
Appears in this Document