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Hunanamycin A, an antibiotic from a marine-derived Bacillus hunanensis

Youcai Hu; Kezhan Wang; John B. MacMillan

(Profiled Author: John B MacMillan)

Organic Letters. 2013;15(2):390-393.


Hunanamycin A, the first natural product with a pyrido[1,2,3-de] quinoxaline-2,3-dione core, was isolated from a marine-derived Bacillus hunanensis. Hunanamycin A is related to a degradation product of riboflavin but has undergone an N-prenylation and subsequent cyclization. The structure, including stereochemistry, was determined by NMR and MS methods. Hunanamycin A exhibits a minimum inhibitory concentration (MIC) of 12.4 μM against the bacterial pathogen Salmonella enterica. © 2013 American Chemical Society.

PMID: 23305153    

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