Scopus Publication Detail
The publication detail shows the title, authors (with indicators showing other profiled authors), information on the publishing organization, abstract and a link to the article in Scopus. This abstract is what is used to create the fingerprint of the publication.
Richard K Bruick; Kevin H Gardner; John B MacMillan; Uttam K Tambar)
Journal of Medicinal Chemistry. 2013;56(4):1739-1747.Abstract
Hypoxia inducible factors (HIFs) are heterodimeric transcription factors induced in a variety of pathophysiological settings, including cancer. We describe the first detailed structure-activity relationship study of small molecules designed to inhibit HIF-2α-ARNT heterodimerization by binding an internal cavity of the HIF-2α PAS-B domain. Through a series of biophysical characterizations of inhibitor-protein interactions (NMR and X-ray crystallography), we have established the structural requirements for artificial inhibitors of the HIF-2α-ARNT PAS-B interaction. These results may serve as a foundation for discovering therapeutic agents that function by a novel mode of action. © 2013 American Chemical Society.
This section shows information related to the publication - computed using the fingerprint of the publication - including related publications, related experts with fingerprints representing significant amounts of overlap between their fingerprint and this publication. The red dots indicate whether those experts or terms appear within the publication, thereby showing potential and actual connections.
Thomas H. Scheuermann; Qiming Li; He-Wen Ma; Jason Key; Lei Zhang; Rui Chen; Joseph A. Garcia; Jacinth Naidoo; Jamie Longgood; Doug E. Frantz; et al.Nature Chemical Biology. 2013;9(4):271-276.
Alys Peisley; Bin Wu; Hui Xu; Zhijian J. Chen; Sun HurNature. 2014;508(7498):110-114.
Thorsten Althoff; Ryan E. Hibbs; Surajit Banerjee; Eric GouauxNature. 2014;512(7514):333-337.
Appears in this Document