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Development of inhibitors of the PAS-B domain of the HIF-2α transcription factor

Jamie L. Rogers; Liela Bayeh; Thomas H. Scheuermann; Jamie Longgood; Jason Key; Jacinth Naidoo; Lisa Melito; Cameron Shokri; Doug E. Frantz; Richard K. Bruick; et al.

(Profiled Authors: Richard K Bruick; Kevin H Gardner; John B MacMillan; Uttam K Tambar)

Journal of Medicinal Chemistry. 2013;56(4):1739-1747.


Hypoxia inducible factors (HIFs) are heterodimeric transcription factors induced in a variety of pathophysiological settings, including cancer. We describe the first detailed structure-activity relationship study of small molecules designed to inhibit HIF-2α-ARNT heterodimerization by binding an internal cavity of the HIF-2α PAS-B domain. Through a series of biophysical characterizations of inhibitor-protein interactions (NMR and X-ray crystallography), we have established the structural requirements for artificial inhibitors of the HIF-2α-ARNT PAS-B interaction. These results may serve as a foundation for discovering therapeutic agents that function by a novel mode of action. © 2013 American Chemical Society.

PMID: 23363003     PMCID: PMC3676484    

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