Scopus Publication Detail
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James F Amatruda; Thomas J Carroll; Chuo Chen; Lawrence Lum; Noelle S Williams; Lishu Zhang)
Journal of Medicinal Chemistry. 2013;56(6):2700-2704.Abstract
Porcupine is a member of the membrane-bound O-acyltransferase family of proteins. It catalyzes the palmitoylation of Wnt proteins, a process required for their secretion and activity. We recently disclosed a class of small molecules (IWPs) as the first reported Porcn inhibitors. We now describe the structure-activity relationship studies and the identification of subnanomolar inhibitors. We also report herein the effects of IWPs on Wnt-dependent developmental processes, including zebrafish posterior axis formation and kidney tubule formation. © 2013 American Chemical Society.
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