Scopus Publication Detail
The publication detail shows the title, authors (with indicators showing other profiled authors), information on the publishing organization, abstract and a link to the article in Scopus. This abstract is what is used to create the fingerprint of the publication.
Development of a locally advanced orthotopic prostate tumor model in rats for assessment of combined modality therapyAmyn A Habib; Jer-Tsong Hsieh; Debabrata Saha; Timothy D Solberg; Kwang Hyun Song; Masaya Takahashi; Dawen Zhao)
International Journal of Oncology. 2013;42(5):1613-1619.Abstract
The purpose of this study was to develop an aggressive locally advanced orthotopic prostate cancer model for assessing high-dose image-guided radiation therapy combined with biological agents. For this study, we used a modified human prostate cancer (PCa) cell line, PC3, in which we knocked down a tumor suppressor protein, DAB2IP (PC3 KD). These prostate cancer cells were implanted into the prostate of nude or Copenhagen rats using either open surgical implantation or a minimally invasive procedure under ultrasound guidance. We report that: i) these DAB2IP-deficient PCa cells form a single focus of locally advanced aggressive tumors in both nude and Copenhagen rats; ii) the resulting tumors are highly aggressive and are poorly controlled after treatment with radiation alone; iii) ultrasound-guided tumor cell implantation can be used successfully for tumor development in the rat prostate; iv) precise measurement of the tumor volume and the treatment planning for radiation therapy can be obtained from ultrasound and MRI, respectively; and v) the use of a fiducial marker for enhanced radiotherapy localization in the rat orthotopic tumor. This model recapitulates radiation-resistant prostate cancers which can be used to demonstrate and quantify therapeutic response to combined modality treatments.
This section shows information related to the publication - computed using the fingerprint of the publication - including related publications, related experts with fingerprints representing significant amounts of overlap between their fingerprint and this publication. The red dots indicate whether those experts or terms appear within the publication, thereby showing potential and actual connections.
Jessica Huamani; Christopher Willey; Dinesh Thotala; Kenneth J. Niermann; Michelle Reyzer; Lauren Leavitt; Cameron Jones; Arthur Fleishcher; Richard Caprioli; Dennis E. Hallahan; et al.International Journal of Radiation Oncology Biology Physics. 2008;71(1):237-246.
Zhaolu Kong; Pavithra Raghavan; Daxing Xie; Thomas Boike; Sandeep Burma; David Chen; Arup Chakraborty; Jer-Tsong Hsieh; Debabrata SahaInternational Journal of Radiation Oncology Biology Physics. 2010;78(4):1210-1218.
Hong Chen; Szu-Wei Tu; Jer-Tsong HsiehJournal of Biological Chemistry. 2005;280(23):22437-22444.
Appears in this Document