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Nicholas G. Cost; Candace F. Granberg; Bruce J. Schlomer; Jonathan E. Wickiser; Patricio C. Gargollo; Linda A. Baker; Dinesh Rakheja(Profiled Authors: Linda A Baker; Dinesh Rakheja; Jonathan E Wickiser)
Urology Journal. 2013;10(1):780-783.Abstract
Purpose: To evaluate the efficacy of needle biopsy for diagnosing Wilms tumor (WT) before chemotherapy. Materials and Methods: We reviewed our institutional experience with Tru-Cut biopsy of pediatnc renal masses in patients who subsequently underwent nephrectomy. We compared biopsy pathology with nephrectomy specimens to determine if biopsy accurately predicted final pathology. Results: Seven children underwent Tru-Cut renal mass biopsy followed by surgical resection. In 4 patients, the final biopsy pathology was definitively read as WT and in 3 subjects, the pathology was read as WT versus hyperplastic nephrogemc rest. In all 7 patients, the nephrectomy pathology confirmed a diagnosis of WT. There were no complications after biopsy, and no patients have had local or regional recurrence. Conclusion: In our experience, pre-therapy Tru-Cut biopsy safely provides an adequate specimen for pathologic review in diagnosing WT.
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