Scopus Publication Detail
The publication detail shows the title, authors (with indicators showing other profiled authors), information on the publishing organization, abstract and a link to the article in Scopus. This abstract is what is used to create the fingerprint of the publication.
Diagnosis of relevant prostate cancer using supplementary cores from magnetic resonance imaging-prompted areas following multiple failed biopsies
Daniel N. Costa; B. Nicolas Bloch; David F. Yao; Martin G. Sanda; Long Ngo; Elizabeth M. Genega; Ivan Pedrosa; William C. DeWolf; Neil M. Rofsky(Profiled Authors: Daniel N Costa; Ivan Pedrosa; Neil M Rofsky)
Magnetic Resonance Imaging. 2013;31(6):947-952.Abstract
Objectives: To establish the value of MRI in targeting re-biopsy for undiagnosed prostate cancer despite multiple negative biopsies and determine clinical relevance of detected tumors. Materials and Methods: Thirty-eight patients who underwent MRI after 2 or more negative biopsies due to continued clinical suspicion and later underwent TRUS-guided biopsy supplemented by biopsy of suspicious areas depicted by MRI were identified. Diagnostic performance of endorectal 3T MRI in diagnosing missed cancer foci was assessed using biopsy results as the standard of reference. Ratio of positive biopsies using systematic versus MRI-prompted approaches was compared. Gleason scores of detected cancers were used as surrogate for clinical relevance. Results: Thirty-four percent of patients who underwent MRI before re-biopsy had prostate cancer on subsequent biopsy. The positive biopsy yield with systematic sampling was 23% versus 92% with MRI-prompted biopsies(p. <. 0.0001). Seventy-seven percent of tumors were detected exclusively in the MRI-prompted zones. Sensitivity, specificity, positive predictive value, negative predictive value and accuracy of MRI to provide a positive biopsy were 92%, 60%, 55%, 94% and 71%, respectively. The anterior gland and apical regions contained most tumors; 75% of cancers detected by MRI-prompted biopsy had Gleason score. ≥. 7. Conclusions: Clinically relevant tumors missed by multiple TRUS-guided biopsies can be detected by a MRI-prompted approach. © 2013 Elsevier Inc.
This section shows information related to the publication - computed using the fingerprint of the publication - including related publications, related experts with fingerprints representing significant amounts of overlap between their fingerprint and this publication. The red dots indicate whether those experts or terms appear within the publication, thereby showing potential and actual connections.
Mirabela Rusu; B. Nicolas Bloch; Carl C. Jaffe; Neil M. Rofsky; Elizabeth M. Genega; Ernest Feleppa; Robert E. Lenkinski; Anant MadabhushiProgress in Biomedical Optics and Imaging - Proceedings of SPIE. 2013;8669.
Hatef Mehrabian; Rajiv Chopra; Anne L. MartelIEEE Transactions on Medical Imaging. 2013;32(4):699-710.
Heling Zhou; Jason H. Stafford; Rami R. Hallac; Liang Zhang; Gang Huang; Ralph P. Mason; Jinming Gao; Philip E. Thorpe; Dawen ZhaoJournal of Biomedical Nanotechnology. 2014;10(5):846-855.
Appears in this Document