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Development of a scalable synthesis of P7C3-A20, a potent neuroprotective agent

Jacinth Naidoo; Christopher J. Bemben; Shawn R. Allwein; Jue Liang; Andrew A. Pieper; Joseph M. Ready

(Profiled Author: Joseph M Ready)

Tetrahedron Letters. 2013;54(33):4429-4431.

Abstract

A scalable synthesis of the neuroprotective agent P7C3-A20 is described. The synthesis has provided hundred-gram batches of the final compound for biological evaluation in rodents primates. The synthesis can be performed without chromatographic purification of intermediates or the final product. © 2013 Elsevier Ltd. All rights reserved.

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