Scopus Publication Detail
The publication detail shows the title, authors (with indicators showing other profiled authors), information on the publishing organization, abstract and a link to the article in Scopus. This abstract is what is used to create the fingerprint of the publication.
Hyeonwoo Kim; Hong Zhang; David Meng; Geoffrey Russell; Joon No Lee; Jin Ye(Profiled Authors: Jin Ye; Hong Zhang)
Journal of Lipid Research. 2013;54(8):2144-2152.Abstract
Ubxd8, a multidomain protein sensor for longchain unsaturated fatty acids (FAs), plays a crucial role to maintain cellular homeostasis of FAs. Ubxd8 polymerizes upon interaction with long-chain unsaturated FAs, but the molecular mechanism involved in this polymerization remains unclear. Here we report that the UAS domain of Ubxd8 mediates this polymerization. We show that a positively charged surface area in the domain is required for the reaction. Mutations changing the positively charged residues in this area to glutamates prevented long-chain unsaturated FAs from inducing oligomerization of Ubxd8. Consequently, the mutant protein no longer responded to regulation by long-chain unsaturated FAs in cultured cells. Long-chain unsaturated FAs also induced polymerization of Fas-associated factor 1 (FAF1), the only other mammalian protein that contains a UAS domain homologous to that of Ubxd8. These results provide further insights into protein- FA interactions by identifying the UAS domain as a motif interacting with long-chain unsaturated FAs. Copyright © 2013 by the American Society for Biochemistry and Molecular Biology, Inc.
This section shows information related to the publication - computed using the fingerprint of the publication - including related publications, related experts with fingerprints representing significant amounts of overlap between their fingerprint and this publication. The red dots indicate whether those experts or terms appear within the publication, thereby showing potential and actual connections.
Hyeonwoo Kim; Jin YeCurrent Opinion in Lipidology. 2014;25(2):118-124.
Jin YeFrontiers in Biology. 2012;7(5):397-403.
Herbert J. Kayden; Rody P. CoxThe Journal of Pediatrics. 1973;83(6):993-998.
Appears in this Document