Scopus Publication Detail
The publication detail shows the title, authors (with indicators showing other profiled authors), information on the publishing organization, abstract and a link to the article in Scopus. This abstract is what is used to create the fingerprint of the publication.
Stem Cells. 2013;31(8):1563-1573.Abstract
LIN28A/B are RNA binding proteins implicated by genetic association studies in human growth and glucose metabolism. Mice with ectopic over-expression of Lin28a have shown related phenotypes. Here, we describe the first comprehensive analysis of the physiologic consequences of Lin28a and Lin28b deficiency in knockout (KO) mice. Lin28a/b-deficiency led to dwarfism starting at different ages, and compound gene deletions showed a cumulative dosage effect on organismal growth. Conditional gene deletion at specific developmental stages revealed that fetal but neither neonatal nor adult deficiency resulted in growth defects and aberrations in glucose metabolism. Tissue- specific KO mice implicated skeletal muscle-deficiency in the abnormal programming of adult growth and metabolism. The effects of Lin28b KO could be rescued by Tsc1 haplo-insufficiency in skeletal muscles. Our data implicate fetal expression of Lin28a/b in the regulation of life-long effects on metabolism and growth, and demonstrate that fetal Lin28b acts at least in part via mTORC1 signaling. © AlphaMed Press.
This section shows information related to the publication - computed using the fingerprint of the publication - including related publications, related experts with fingerprints representing significant amounts of overlap between their fingerprint and this publication. The red dots indicate whether those experts or terms appear within the publication, thereby showing potential and actual connections.
Michele R. HutchisonPLoS ONE. 2013;8(6).
Ning Liu; Andrew H. Williams; Yuri Kim; John McAnally; Svetlana Bezprozvannaya; Lillian B. Sutherland; James A. Richardson; Rhonda Bassel-Duby; Eric N. OlsonProceedings of the National Academy of Sciences of the United States of America. 2007;104(52):20844-20849.
Teresa S. Hyun; Lina Li; Katherine I. Oravecz-Wilson; Sarah V. Bradley; Melissa M. Provot; Anthony J. Munaco; Ikuko F. Mizukami; Hanshi Sun; Theodora S. RossMolecular and Cellular Biology. 2004;24(10):4329-4340.
Appears in this Document