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A comparative study of short- and long-TE 1H MRS at 3 T for in vivo detection of 2-hydroxyglutarate in brain tumors

Changho Choi; Sandeep Ganji; Keith Hulsey; Akshay Madan; Zoltan Kovacs; Ivan Dimitrov; Song Zhang; Kumar Pichumani; Dianne Mendelsohn; Bruce Mickey; et al.

(Profiled Authors: Robert Bachoo; Changho Choi; Ralph J DeBerardinis; Zoltan Kovacs; Elizabeth A Maher; Craig R Malloy; Dianne B Mendelsohn; Bruce E Mickey; Song Zhang)

NMR in Biomedicine. 2013;26(10):1242-1250.


2-Hydroxyglutarate (2HG) is produced in gliomas with mutations of isocitrate dehydrogenase (IDH) 1 and 2. The 1H resonances of the J-coupled spins of 2HG are extensively overlapped with signals from other metabolites. Here, we report a comparative study at 3 T of the utility of the point-resolved spectroscopy sequence with a standard short TE (35 ms) and a long TE (97 ms), which had been theoretically designed for the detection of the 2HG 2.25-ppm resonance. The performance of the methods is evaluated using data from phantoms, seven healthy volunteers and 22 subjects with IDH-mutated gliomas. The results indicate that TE=97 ms provides higher detectability of 2HG than TE=35 ms, and that this improved capability is gained when data are analyzed with basis spectra that include the effects of the volume localizing radiofrequency and gradient pulses. © 2013 John Wiley & Sons, Ltd.

PMID: 23592268     PMCID: PMC3733061    

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