Scopus Publication Detail
The publication detail shows the title, authors (with indicators showing other profiled authors), information on the publishing organization, abstract and a link to the article in Scopus. This abstract is what is used to create the fingerprint of the publication.
Victor J. Hernandez; Jian Weng; Peter Ly; Shanica Pompey; Hongyun Dong; Lopa Mishra; Margaret Schwarz; Richard G.W. Anderson; Peter Michaely(Profiled Authors: Peter A Michaely; Margaret Schwarz)
Cavin-3 is a tumor suppressor protein of unknown function. Using both in vivo and in vitro approaches, we show that cavin-3 dictates the balance between ERK and Akt signaling. Loss of cavin-3 increases Akt signaling at the expense of ERK, while gain of cavin-3 increases ERK signaling at the expense Akt. Cavin-3 facilitates signal transduction to ERK by anchoring caveolae to the membrane skeleton of the plasma membrane via myosin-1c. Caveolae are lipid raft specializations that contain an ERK activation module and loss of the cavin-3 linkage reduces the abundance of caveolae, thereby separating this ERK activation module from signaling receptors. Loss of cavin-3 promotes Akt signaling through suppression of EGR1 and PTEN. The in vitro consequences of the loss of cavin-3 include induction of Warburg metabolism (aerobic glycolysis), accelerated cell proliferation, and resistance to apoptosis. The in vivo consequences of cavin-3 knockout are increased lactate production and cachexia. © Hernandez et al.
This section shows information related to the publication - computed using the fingerprint of the publication - including related publications, related experts with fingerprints representing significant amounts of overlap between their fingerprint and this publication. The red dots indicate whether those experts or terms appear within the publication, thereby showing potential and actual connections.
Subhashis Banerjee; Ken L. Chambliss; Chieko Mineo; Philip W. ShaulSteroids. 2014;81:64-69.
Tomonori Ishikawa; Ivan S. Yuhanna; Junko Umetani; Wan-Ru Lee; Kenneth S. Korach; Philip W. Shaul; Michihisa UmetaniJournal of Clinical Investigation. 2013;123(8):3488-3497.
Michael S Brown; Joseph L GoldsteinThe Journal of cell biology. 2011;193(4):601-603.
Appears in this Document