• Home
  •  > Scopus Publication Detail

Scopus Publication Detail

The publication detail shows the title, authors (with indicators showing other profiled authors), information on the publishing organization, abstract and a link to the article in Scopus. This abstract is what is used to create the fingerprint of the publication.

27-Hydroxycholesterol promotes cell-autonomous, ER-positive breast cancer growth

Qian Wu; Tomonori Ishikawa; Rosa Sirianni; Hao Tang; Jeffrey G. McDonald; Ivan S. Yuhanna; Bonne Thompson; Luc Girard; Chieko Mineo; Rolf A. Brekken; et al.

(Profiled Authors: Rolf A Brekken; Luc Girard; Jeffrey G McDonald; Chieko Mineo; Philip W Shaul; Rosa Sirianni; Michihisa Umetani; Yang Xie; Hao Tang)

Cell Reports. 2013;5(3):637-645.


To date, estrogen is the only known endogenous estrogen receptor (ER) ligand that promotes ER+ breast tumor growth. We report that the cholesterol metabolite 27-hydroxycholesterol (27HC) stimulates MCF-7 cell xenograft growth in mice. More importantly, in ER+ breast cancer patients, 27HC content in normal breast tissue is increased compared to that in cancer-free controls, and tumor 27HC content is further elevated. Increased tumor 27HC is correlated with diminished expression of CYP7B1, the 27HC metabolizing enzyme, and reduced expression of CYP7B1 in tumors is associated with poorer patient survival. Moreover, 27HC is produced by MCF-7 cells, and it stimulates cell-autonomous, ER-dependent, and GDNF-RET-dependent cell proliferation. Thus, 27HC is a locally modulated, nonaromatized ER ligand that promotes ER+ breast tumor growth

PMID: 24210818     PMCID: PMC3950897    

Scientific Context

This section shows information related to the publication - computed using the fingerprint of the publication - including related publications, related experts with fingerprints representing significant amounts of overlap between their fingerprint and this publication. The red dots indicate whether those experts or terms appear within the publication, thereby showing potential and actual connections.

Related Publications

Related Topics

Appears in this Publication Appears in this Document

Related Experts

Author of this Publication Author of this Document