Scopus Publication Detail
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Yanggan Wang; Samvit Tandan; Joseph A. Hill(Profiled Author: Joseph A Hill)
Trends in Cardiovascular Medicine. 2014;24(1):14-22.Abstract
Calcineurin, a serine-threonine-specific, Ca2+-calmodulin-activated protein phosphatase, conserved from yeast to humans, plays a key role in regulating cardiac development, hypertrophy, and pathological remodeling. Recent studies demonstrate that calcineurin regulates cardiomyocyte ion channels and receptors in a manner which often entails direct interaction with these target proteins. Here, we review the current state of knowledge of calcineurin-mediated regulation of ion channels in the myocardium with emphasis on the transient outward potassium current (I
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