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GdDO3NI, a nitroimidazole-based T 1 MRI contrast agent for imaging tumor hypoxia in vivo Topical Issue on Metal-Based MRI Contrast Agents. Guest editor: Valerie C. Pierre
Praveen K. Gulaka; Federico Rojas-Quijano; Zoltan Kovacs; Ralph P. Mason; A. Dean Sherry; Vikram D. Kodibagkar(Profiled Authors: Zoltan Kovacs; Ralph P Mason; Dean Sherry)
Journal of Biological Inorganic Chemistry. 2014;19(2):271-279.Abstract
Tumor hypoxia is known to affect sensitivity to radiotherapy and promote development of metastases; therefore, the ability to image tumor hypoxia in vivo could provide useful prognostic information and help tailor therapy. We previously demonstrated in vitro evidence for selective accumulation of a gadolinium tetraazacyclododecanetetraacetic acid monoamide conjugate of 2-nitroimidazole (GdDO3NI), a magnetic resonance imaging T
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