• Home
  •  > Scopus Publication Detail

Scopus Publication Detail

The publication detail shows the title, authors (with indicators showing other profiled authors), information on the publishing organization, abstract and a link to the article in Scopus. This abstract is what is used to create the fingerprint of the publication.


Identification and characterization of a suite of tumor targeting peptides for non-small cell lung cancer

Michael J. McGuire; Bethany Powell Gray; Shunzi Li; Dorothy Cupka; Lauren Averett Byers; Lei Wu; Shaghayegh Rezaie; Ying-Horng Liu; Naveen Pattisapu; James Issac; et al.

(Profiled Authors: John D Minna; Xian-Jin Xie)

Scientific Reports. 2014;4.

Abstract

Tumor targeting ligands are emerging components in cancer therapies. Widespread use of targeted therapies and molecular imaging is dependent on increasing the number of high affinity, tumor-specific ligands. Towards this goal, we biopanned three phage-displayed peptide libraries on a series of well-defined human non-small cell lung cancer (NSCLC) cell lines, isolating 11 novel peptides. The peptides show distinct binding profiles across 40 NSCLC cell lines and do not bind normal bronchial epithelial cell lines. Binding of specific peptides correlates with onco-genotypes and activation of particular pathways, such as EGFR signaling, suggesting the peptides may serve as surrogate markers. Multimerization of the peptides results in cell binding affinities between 0.0071-40â.nM. The peptides home to tumors in vivo and bind to patient tumor samples. This is the first comprehensive biopanning for isolation of high affinity peptidic ligands for a single cancer type and expands the diversity of NSCLC targeting ligands.

Scientific Context


Context is not available for this document. This can mean several things, this document may not have enough text to produce a Fingerprint, or there are no Similar Experts and publications to display.