Scopus Publication Detail
The publication detail shows the title, authors (with indicators showing other profiled authors), information on the publishing organization, abstract and a link to the article in Scopus. This abstract is what is used to create the fingerprint of the publication.
Eunmyong Lee; Yeon Koo; Aylwin Ng; Yongjie Wei; Kate Luby-Phelps; Amy Juraszek; Ramnik J. Xavier; Ondine Cleaver; Beth Levine; James F. Amatruda(Profiled Authors: James F Amatruda; Ondine Cleaver; Beth Levine; Yongjie Wei)
Genetic analyses indicate that autophagy, an evolutionarily conserved lysosomal degradation pathway, is essential for eukaryotic differentiation and development. However, little is known about whether autophagy contributes to morphogenesis during embryogenesis. To address this question, we examined the role of autophagy in the early development of zebrafish, a model organism for studying vertebrate tissue and organ morphogenesis. Using zebrafish that transgenically express the fluorescent autophagy reporter protein, GFP-LC3, we found that autophagy is active in multiple tissues, including the heart, during the embryonic period. Inhibition of autophagy by morpholino knockdown of essential autophagy genes (including atg5, atg7, and becn1) resulted in defects in morphogenesis, increased numbers of dead cells, abnormal heart structure, and reduced organismal survival. Further analyses of cardiac development in autophagy-deficient zebrafish revealed defects in cardiac looping, abnormal chamber morphology, aberrant valve development, and ectopic expression of critical transcription factors including foxn4, tbx5, and tbx2. Consistent with these results, Atg5 -deficient mice displayed abnormal Tbx2 expression and defects in valve development and chamber septation. Thus, autophagy plays an essential, conserved role in cardiac morphogenesis during vertebrate development. © 2014 Landes Bioscience.
This section shows information related to the publication - computed using the fingerprint of the publication - including related publications, related experts with fingerprints representing significant amounts of overlap between their fingerprint and this publication. The red dots indicate whether those experts or terms appear within the publication, thereby showing potential and actual connections.
Francesco Cecconi; Beth LevineDevelopmental Cell. 2008;15(3):344-357.
Congcong He; Clinton R. Bartholomew; Weibin Zhou; Daniel J. KlionskyAutophagy. 2009;5(4):520-526.
Jane E. JohnsonTrends in Neurosciences. 2003;26(8):395-396.
Appears in this Document