Scopus Publication Detail
The publication detail shows the title, authors (with indicators showing other profiled authors), information on the publishing organization, abstract and a link to the article in Scopus. This abstract is what is used to create the fingerprint of the publication.
Smooth pursuit eye movement, prepulse inhibition, and auditory paired stimuli processing endophenotypes across the schizophrenia-bipolar disorder psychosis dimension
Elena I. Ivleva; Amanda F. Moates; Jordan P. Hamm; Ira H. Bernstein; Hugh B. O'Neill; Darwynn Cole; Brett A. Clementz; Gunvant K. Thaker; Carol A. Tamminga(Profiled Authors: Ira Bernstein; Elena Ivleva; Carol A Tamminga)
Schizophrenia Bulletin. 2014;40(3):642-652.Abstract
Background:This study examined smooth pursuit eye movement (SPEM), prepulse inhibition (PPI), and auditory event-related potentials (ERP) to paired stimuli as putative endophenotypes of psychosis across the schizophrenia-bipolar disorder dimension. Methods:Sixty-four schizophrenia probands (SZP), 40 psychotic bipolar I disorder probands (BDP), 31 relatives of SZP (SZR), 26 relatives of BDP (BDR), and 53 healthy controls (HC) were tested. Standard clinical characterization, SPEM, PPI, and ERP measures were administered. Results:There were no differences between either SZP and BDP or SZR and BDR on any of the SPEM, PPI, or ERP measure. Compared with HC, SZP and BDP had lower SPEM maintenance and predictive pursuit gain and ERP theta/alpha and beta magnitudes to the initial stimulus. PPI did not differ between the psychosis probands and HC. Compared with HC, SZR and BDR had lower predictive pursuit gain and ERP theta/alpha and beta magnitudes to the first stimulus with differences ranging from a significant to a trend level. Neither active symptoms severity nor concomitant medications were associated with neurophysiological outcomes. SPEM, PPI, and ERP scores had low intercorrelations. Conclusion:These findings support SPEM predictive pursuit and lower frequency auditory ERP activity in a paired stimuli paradigm as putative endophenotypes of psychosis common to SZ and BD probands and relatives. PPI did not differ between the psychosis probands and HC. Future studies in larger scale psychosis family samples targeting putative psychosis endophenotypes and underlying molecular and genetic mediators may aid in the development of biology-based diagnostic definitions. © The Author 2013. Published by Oxford University Press on behalf of the Maryland Psychiatric Research Center. All rights reserved.
This section shows information related to the publication - computed using the fingerprint of the publication - including related publications, related experts with fingerprints representing significant amounts of overlap between their fingerprint and this publication. The red dots indicate whether those experts or terms appear within the publication, thereby showing potential and actual connections.
Lauren E. Ethridge; Jordan P. Hamm; Godfrey D. Pearlson; Carol A. Tamminga; John A. Sweeney; Matcheri S. Keshavan; Brett A. ClementzBiological Psychiatry. 2015;77(2):127-136.
Amanda F. Moates; Elena I. Ivleva; Hugh B. O'Neill; Nithin Krishna; C. Munro Cullum; Gunvant K. Thaker; Carol A. TammingaBiological Psychiatry. 2012;72(9):752-757.
Pawel Skudlarski; David J. Schretlen; Gunvant K. Thaker; Michael C. Stevens; Matcheri S. Keshavan; John A. Sweeney; Carol A. Tamminga; Brett A. Clementz; Kasey O'Neil; Godfrey D. PearlsonAmerican Journal of Psychiatry. 2013;170(8):886-898.
Appears in this Document