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Rami R. Hallac; Heling Zhou; Rajesh Pidikiti; Kwang Song; Strahinja Stojadinovic; Dawen Zhao; Timothy Solberg; Peter Peschke; Ralph P. Mason(Profiled Authors: Ralph P Mason; Timothy D Solberg; Kwang Hyun Song; Strahinja Stojadinovic; Dawen Zhao)
Magnetic Resonance in Medicine. 2014;71(5):1863-1873.Abstract
Purpose To examine the potential use of blood oxygenation level dependent (BOLD) and tissue oxygenation level dependent (TOLD) contrast MRI to assess tumor oxygenation and predict radiation response. Methods BOLD and TOLD MRI were performed on Dunning R3327-AT1 rat prostate tumors during hyperoxic gas breathing challenge at 4.7 T. Animals were divided into two groups. In Group 1 (n = 9), subsequent 19F MRI based on spin lattice relaxation of hexafluorobenzene reporter molecule provided quantitative oximetry for comparison. For Group 2 rats (n = 13) growth delay following a single dose of 30 Gy was compared with preirradiation BOLD and TOLD assessments. Results Oxygen (100%O
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