Scopus Publication Detail
The publication detail shows the title, authors (with indicators showing other profiled authors), information on the publishing organization, abstract and a link to the article in Scopus. This abstract is what is used to create the fingerprint of the publication.
Genes and Development. 2014;28(9):971-982.Abstract
Wilms Tumor, the most common pediatric kidney cancer, evolves from the failure of terminal differentiation of the embryonic kidney. Here we show that overexpression of the heterochronic regulator Lin28 during kidney development in mice markedly expands nephrogenic progenitors by blocking their final wave of differentiation, ultimately resulting in a pathology highly reminiscent of Wilms tumor. Using lineage-specific promoters to target Lin28 to specific cell types, we observed Wilms tumor only when Lin28 is aberrantly expressed in multiple derivatives of the intermediate mesoderm, implicating the cell of origin as a multipotential renal progenitor. We show that withdrawal of Lin28 expression reverts tumorigenesis and markedly expands the numbers of glomerulus-like structures and that tumor formation is suppressed by enforced expression of Let-7 microRNA. Finally, we demonstrate overexpression of the LIN28B paralog in a significant percentage of human Wilms tumor. Our data thus implicate the Lin28/Let-7 pathway in kidney development and tumorigenesis. © 2014 Urbach et al.
This section shows information related to the publication - computed using the fingerprint of the publication - including related publications, related experts with fingerprints representing significant amounts of overlap between their fingerprint and this publication. The red dots indicate whether those experts or terms appear within the publication, thereby showing potential and actual connections.
Tibor Nadasdy; Jürgen Roth; Debbie L. Johnson; Barbara L. Bane; Arthur Weinberg; Regina Verani; Fred G. SilvaHuman Pathology. 1993;24(4):413-419.
Hiroshi Miwa; Gail E. Tomlinson; Charles F. Timmons; Vicki Huff; Susan L. Cohn; Louise C. Strong; Grady F. SaundersJournal of the National Cancer Institute. 1992;84(3):181-187.
Payal Kapur; Dinesh RakhejaPediatric and Developmental Pathology. 2011;14(1):16-19.
Appears in this Document