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Carpatamides A-C, cytotoxic arylamine derivatives from a marine-derived streptomyces sp.

Peng Fu; Melissa Johnson; Hong Chen; Bruce A. Posner; John B. MacMillan

(Profiled Authors: John B MacMillan; Bruce A Posner)

Journal of Natural Products. 2014;77(5):1245-1248.


Three new acylated arylamine derivatives (1-3), carpatamides A-C, were isolated from a marine-derived Streptomyces sp. based on activity screening against non-small-cell lung cancer (NSCLC). The structures of 1-3 were established on the basis of comprehensive spectroscopic analyses and chemical methods. Compounds 1 and 3 showed moderate cytotoxicity against NSCLC cell lines HCC366, A549, and HCC44 with IC50 values ranging from 2.2 to 8.4 μM. © 2014 The American Chemical Society and American Society of Pharmacognosy.

PMID: 24754815     PMCID: PMC4035114    

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