Scopus Publication Detail
The publication detail shows the title, authors (with indicators showing other profiled authors), information on the publishing organization, abstract and a link to the article in Scopus. This abstract is what is used to create the fingerprint of the publication.
The histone variant MacroH2A1 regulates target gene expression in part by recruiting the transcriptional coregulator PELP1
Kristine M. Hussey; Hongshan Chen; Christine Yang; Eugene Park; Nasun Hah; Hediye Erdjument-Bromage; Paul Tempst; Matthew J. Gamble; W. Lee Kraus(Profiled Author: William L Kraus)
Molecular and Cellular Biology. 2014;34(13):2437-2449.Abstract
MacroH2A1 is a histone variant harboring an ~25-kDa carboxyl-terminal macrodomain. Due to its enrichment on the inactive X chromosome, macroH2A1 was thought to play a role in transcriptional repression. However, recent studies have shown that macroH2A1 occupies autosomal chromatin and regulates genes in a context-specific manner. The macrodomain may play a role in the modulation of gene expression outcomes via physical interactions with effector proteins, which may depend on the ability of the macrodomain to bind NAD+ metabolite ligands. Here, we identify proline, glutamic acid, and leucine-rich protein 1 (PELP1), a chromatin-associated factor and transcriptional coregulator, as a ligand-independent macrodomain-interacting factor. We used chromatin immunoprecipitation coupled with tiling microarrays (ChIP-chip) to determine the genomic localization of PELP1 in MCF-7 human breast cancer cells. We find that PELP1 genomic localization is highly correlated with that of macroH2A1. Additionally, PELP1 positively correlates with heterochromatic chromatin marks and negatively correlates with active transcription marks, much like macroH2A1. MacroH2A1 specifically recruits PELP1 to the promoters of macroH2A1 target genes, but macroH2A1 occupancy occurs independent of PELP1. This recruitment allows macroH2A1 and PELP1 to cooperatively regulate gene expression outcomes. © 2014, American Society for Microbiology.
This section shows information related to the publication - computed using the fingerprint of the publication - including related publications, related experts with fingerprints representing significant amounts of overlap between their fingerprint and this publication. The red dots indicate whether those experts or terms appear within the publication, thereby showing potential and actual connections.
A R Daniel; A L Gaviglio; T P Knutson; J H Ostrander; A B D'Assoro; P Ravindranathan; Y Peng; G V Raj; D Yee; C A LangeOncogene. 2014.
Vijay K. Gonugunta; Lu Miao; Gangadhara R. Sareddy; Preethi Ravindranathan; Ratna Vadlamudi; Ganesh V. RajEndocrine-Related Cancer. 2014;21(4):T79-T86.
W.T. Garrard; J. BonnerJournal of Biological Chemistry. 1974;249(17):5570-5579.
Appears in this Document