Scopus Publication Detail
The publication detail shows the title, authors (with indicators showing other profiled authors), information on the publishing organization, abstract and a link to the article in Scopus. This abstract is what is used to create the fingerprint of the publication.
Actin cytoskeleton reorganization by syk regulates fcγ receptor responsiveness by increasing its lateral mobility and clustering
Valentin Jaumouillé; Yoav Farkash; Khuloud Jaqaman; Raibatak Das; Clifford A. Lowell; Sergio Grinstein(Profiled Author: Khuloud Jaqaman)
Developmental Cell. 2014;29(5):534-546.Abstract
Clustering of immunoreceptors upon association with multivalent ligands triggers important responses including phagocytosis, secretion of cytokines, and production of immunoglobulins. We applied single-molecule detection and tracking methods to study the factors that control the mobility and clustering of phagocytic Fcγ receptors (FcγR). While the receptors exist as monomers in resting macrophages, two distinct populations were discernible based on their mobility: some diffuse by apparent free motion, while others are confined within submicron boundaries that reduce the frequency of spontaneous collisions. Src-family and Syk kinases determine the structure of the actin cytoskeleton, which is fenestrated, accounting for the heterogeneous diffusion of the FcγR. Stimulation of these kinases during phagocytosis induces reorganization of the cytoskeleton both locally and distally in a manner that alters receptor mobility and clustering, generating a feedback loop that facilitates engagement of FcγR at the tip of pseudopods, directing the progression of phagocytosis. © 2014 Elsevier Inc.
This section shows information related to the publication - computed using the fingerprint of the publication - including related publications, related experts with fingerprints representing significant amounts of overlap between their fingerprint and this publication. The red dots indicate whether those experts or terms appear within the publication, thereby showing potential and actual connections.
Yuntao S. Mao; Helen L. YinPflugers Archiv European Journal of Physiology. 2007;455(1):5-18.
S.G. Filler; J.N. Swerdloff; C. Hobbs; P.M. LuckettInfection and Immunity. 1995;63(3):976-983.
Yuntao S Mao; Masaki Yamaga; Xiaohui Zhu; Yongjie Wei; Hui-Qiao Sun; Jing Wang; Mia Yun; Yanfeng Wang; Gilbert Di Paolo; Michael Bennett; et al.The Journal of cell biology. 2009;184(2):281-296.
Appears in this Document