Publication Detail

The publication detail shows the title, authors (with indicators showing other profiled authors), information on the publishing organization, abstract and a link to the article in PubMed. This abstract is what is used to create the fingerprint of the publication. If any grants are referenced by the publication, they will be listed here as well.

Differences in allergic sensitization by self-reported race and genetic ancestry.

James J Yang; Esteban G Burchard; Shweta Choudhry; Christine C Johnson; Dennis R Ownby; David Favro; Justin Chen; Matthew Akana; Connie Ha; Pui-Yan Kwok; et al. (Profiled Authors: Christine Cole Johnson; Christine LM Joseph; L Keoki Williams; James Yang)

Department of Biostatistics and Research Epidemiology, Henry Ford Health System, Detroit, MI 48202, USA.
The Journal of allergy and clinical immunology 2008;122(4):820-827.e9.

BACKGROUND: Many allergic conditions occur more frequently in African American patients when compared with white patients; however, it is not known whether this represents genetic predisposition or disparate environmental exposures. OBJECTIVE: We sought to assess the relationship of self-reported race and genetic ancestry to allergic sensitization. METHODS: We included 601 women enrolled in a population-based cohort study whose self-reported race was African American or white. Genetic ancestry was estimated by using markers that differentiate West African and European ancestry. We assessed the relationship between allergic sensitization (defined as > or =1 allergen-specific IgE results) and both self-reported race and genetic ancestry. Regression models adjusted for sociodemographic variables, environmental exposures, and location of residence. RESULTS: The average proportion of West African ancestry in African American participants was 0.69, whereas the mean proportion of European ancestry in white participants was 0.79. Self-reported African American race was associated with allergic sensitization when compared with those who reported being white (adjusted odds ratio, 2.19; 95% CI, 1.22-3.93), even after adjusting for other variables. Genetic ancestry was not significantly associated with allergic sensitization after accounting for location of residence (adjusted odds ratio, 2.09 for urban vs suburban residence; 95% CI, 1.32-3.31). CONCLUSION: Self-reported race and location of residence appeared to be more important predictors of allergic sensitization when compared with genetic ancestry, suggesting that the disparity in allergic sensitization by race might be primarily a result of environmental factors rather than genetic differences.

4 Originating Grant

• 1.

  Williams, Keoki

  USING INFORMATION TECHNOLOGY TO IMPROVE ASTHMA ADHERENCE

  1 September 2005 - 30 June 2009

  NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

  Total Funding: $ 1,385,612

• 2.

  Williams, Keoki

  Mechanism of Endotoxin's Effect On Allergy Risk

  15 August 2004 - 31 January 2009

  NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

  Total Funding: $ 2,936,688

• 3.

  Johnson, Christinec

  Early Environmental Hygiene and Pediatric Atopy

  15 July 2002 - 30 April 2008

  NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

  Total Funding: $ 2,897,612

• 4.

  Johnson, Christinec

  Early Environmental Hygiene and Pediatric Asthma

  1 January 2002 - 31 August 2009

  NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

  Total Funding: $ 1,470,410

Scientific Context

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