Robert D Lasley

Publication Detail

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Beneficial effects of adenosine A(2a) agonist CGS-21680 in infarcted and stunned porcine myocardium.

R D Lasley; M S Jahania; R M Mentzer (Profiled Authors: Mohammed Salik Jahania; Robert D Lasley; Robert Mentzer)

Department of Surgery, University of Kentucky College of Medicine, Lexington, Kentucky 40536, USA. rlasley@pop.uky.edu
American journal of physiology. Heart and circulatory physiology 2001;280(4):H1660-6.

Although there are conflicting results on whether adenosine infusion during reperfusion alters infarct size, there are several reports that indicate adenosine A(2a) agonists reduce infarct size. There are also reports that the A(2a) agonist CGS-21680 increases cAMP and contractility in ventricular myocytes. The purpose of this study was to determine whether low-dose intracoronary infusions of CGS-21680 during reperfusion exert any beneficial effects in irreversibly and reversibly injured myocardium. Open-chest pigs were submitted to 60 min of coronary artery occlusion and 3 h of reperfusion. Treated pigs were administered intracoronary CGS-21680 (0.2 microg x kg(-1) x min(-1)) for the first 60 min of reperfusion. Pigs submitted to regional stunning (15 min ischemia) were treated with intracoronary CGS-21680 (0.15 microg x kg(-1) x min(-1)) after 2 h of reperfusion. In the infarct protocol, CGS-21680 reduced infarct size from 62 +/- 2% of the region at risk to 36 +/- 2%. In stunned myocardium, CGS increased load-independent regional preload recruitable stroke work and area by > or =70%, but the same infusion in normal myocardium was associated with no inotropic effect. Both beneficial effects were associated with little systemic hemodynamic effects. These findings suggest that reperfusion infusions of low doses of the A(2a) agonist CGS-21680 exert beneficial effects in reversibly and irreversibly injured myocardium.

1 Originating Grant

• 1.

  MENTZER, ROBERT M

  Autophagy, Adenosine and Pyruvate Protection During Heart Surgery

  1 June 1996 - 31 May 2013

  NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

  Total Funding: $ 6,407,464

Scientific Context

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