Publication Detail

The publication detail shows the title, authors (with indicators showing other profiled authors), information on the publishing organization, abstract and a link to the article in PubMed. This abstract is what is used to create the fingerprint of the publication. If any grants are referenced by the publication, they will be listed here as well.

Effects of cardiac support device on reverse remodeling: molecular, biochemical, and structural mechanisms.

Hani N Sabbah (Profiled Author: Hani N Sabbah)

Department of Medicine, Division of Cardiovascular Medicine, Henry Ford Health System, Detroit, Michigan 48202, USA.
Journal of cardiac failure 2004;10(6 Suppl):S207-14.

Progressive left ventricular (LV) dilation is a characteristic feature of heart failure and is invariably associated with poor long-term prognosis. This review discusses observations made in dogs with chronic heart failure using a passive mechanical containment device, the Acorn Cardiac Support Device (CSD), which is designed to prevent progressive LV enlargement. Studies have shown that, in addition to preventing LV dilation, long-term therapy with the CSD also improved LV ejection fraction, tended to normalize LV shape, reduced LV wall stress, and reduced or eliminated functional mitral regurgitation. At the cellular level, the CSD attenuates cardiomyocyte hypertrophy, reduced oxygen diffusion distance and downregulated stretch response proteins. The CSD also improved calcium cycling within the sarcoplasmic reticulum and upregulated mRNA gene expression for alpha-myosin heavy chain. These findings, when viewed in concert, provide an explanation for mechanisms that may be responsible for the improvement in LV function seen in dogs with heart after long-term CSD therapy.

1 Originating Grant

• 1.

  Sabbah, Hani N

  PROGRESSION OF HEART FAILURE

  1 April 1994 - 31 December 2003

  NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

  Total Funding: $ 2,329,997

Scientific Context

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