Pediatrics-Neurology

Publication Detail

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Sensitive diffusion tensor imaging quantification method to identify language pathway abnormalities in children with developmental delay.

Sai Prasad Gopal; Vijay Narayan Tiwari; Amy L Veenstra; Ajay Kumar; Michael Behen; Harry T Chugani; Senthil K Sundaram (Profiled Authors: Michael E Behen; Harry Chugani; Senthil K Sundaram)

Department of Pediatrics and Neurology, Wayne State University School of Medicine, Detroit, MI, USA.
The Journal of pediatrics 2012;160(1):147-51.

OBJECTIVE: To investigate whether abnormal regional white matter architecture in the perisylvian region could be used as an easy and sensitive quantitative method to demonstrate language pathway abnormalities in children with developmental delay (DD). STUDY DESIGN: We performed diffusion tensor imaging in 15 DD subjects (age, 61.1 ± 20.9 months) and 15 age-matched typically developing (TD) children (age, 68.4 ± 19.2 months). With diffusion tensor imaging color-coded orientation maps, we quantified the fraction of fibers in the perisylvian region that are oriented in anteroposterior (AP) and mediolateral (ML) directions, and their ratio (AP/ML) was calculated. RESULTS: The AP/ML ratio was more sensitive than tractography in characterizing perisylvian regional abnormalities in DD children. The AP/ML ratio of the left perisylvian region was significantly lower in DD children compared with TD children (P = .03). The ML component of bilateral perisylvian regions was significantly higher in DD children compared with TD children (P = .01 [left] and P = .004 [right]). No significant difference was found in the AP component in the two groups. A significant negative correlation of the left ML component with Vineland communication skills was observed (r = -0.657, P = .011). CONCLUSIONS: The AP/ML ratio appears to be a sensitive indicator of regional white matter architectural abnormalities in the perisylvian region of DD children.

1 Originating Grant

• 1.

  SUNDARAM, SENTHIL

  Diffusion tensor imaging biomarker in developmental delay

  30 September 2009 - 30 November 2014

  EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH &HUMAN DEVELOPMENT

  Total Funding: $ 679,609

Scientific Context

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